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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM503718
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
181±n/a nM
Citation
 Boehm, M; Cabral, S; Dowling, MS; Futatsugi, K; Huard, K; Lee, EC; Londregan, AT; Polivkova, J; Price, DA; Li, Q Diacylglycerol acyl transferase 2 inhibitors US Patent  US11034678 Publication Date 6/15/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM503718
Synonyms:
US11034678, Example 3.4
Type:
Small organic molecule
Emp. Form.:
C20H20N6O4
Mol. Mass.:
408.4106
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(nn1)C(=O)N[C@H]1CCOC1
Structure:
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