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Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM399215
Substrate
n/a
Meas. Tech.
Competition Binding Assay
IC50
>50000±n/a nM
Citation
 Roberts, E; Rosen, H; Urbano, M; Guerrero, M Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent  US11034691 Publication Date 6/15/2021 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM399215
Synonyms:
US10323029, Generic formula 52474 IB | US11034691, CYM generic formula 52474 IB
Type:
Small organic molecule
Emp. Form.:
C21H14Cl3N3O
Mol. Mass.:
430.714
SMILES:
Cc1cc(ccc1C#N)C(=O)N[C@@H](c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cn1 |r|
Structure:
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