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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM399348
Substrate
n/a
Meas. Tech.
Competition Binding Assay
IC50
1400±n/a nM
Citation
 Roberts, E; Rosen, H; Urbano, M; Guerrero, M Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent  US11034691 Publication Date 6/15/2021 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Human
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM399348
Synonyms:
US10323029, Generic formula 52664 IB | US11034691, CYM generic formula 52664 IB
Type:
Small organic molecule
Emp. Form.:
C20H11Cl3FN3O
Mol. Mass.:
434.678
SMILES:
Fc1cc(ccc1C#N)C(=O)N[C@@H](c1ccc(Cl)cc1)c1ncc(Cl)cc1Cl |r|
Structure:
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