Report error Found 114 Enz. Inhib. hit(s) for PDB: 1JKH
Displayed 1 to 50 (of 114 total ) | Next | Last >>
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.0910nMAssay Description:Inhibition of HIV-1BH10 reverse transcriptase expressed in Escherichia coli assessed as polymerization by real time FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.0910nMAssay Description:Inhibition of wild type HIV-1 NL4-3 reverse transcriptase using random mRNA as template and GADPH as primer measured at 42 degreeC for 5 mins, 95 deg...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against wild-type reverse transcriptase of HIV-1More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity towards wild type HIV-1 reverse transcriptase (as per ref 10 in the article)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical
Yamanouchi Pharmaceutical
Affinity DataIC50: 4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataEC50: 4nMAssay Description:Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) by 50%More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against SO561945 (HIV 1 mutant RT) viral infection of MT-4 cellsMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical
Yamanouchi Pharmaceutical
Affinity DataIC50: 4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataEC50: 5.40nMAssay Description:Inhibition of HIV-1 p66/p51 reverse transcriptase Y181C mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical
Yamanouchi Pharmaceutical
Affinity DataIC50: 6nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into wild type RT measured after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into template incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into template incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataKi: 8.5nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inhibition of HIV1 reverse transcriptase Y188C mutant in 293T cellsMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 9.5nMAssay Description:Inhibitory activity against R172A mutant reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant wild-type HIV1 p66/p51 reverse transcriptase assessed as inhibition of [3H]dGTP incorporation using poly (rA) as templates ...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of HIV-1 reverse transcriptase assessed as assessed as reduction of biotin-dUTP incorporation into protein incubated for 1 hrs by ELISA an...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of HIV-1 reverse transcriptase using [2,8-3H]dGTP as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorimetric anal...More data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of HIV1 isolate R8 reverse transcriptase K103N mutant after 90 mins by electrochemiluminescence analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction of biotin-dUTP incorporation into protein using ABTS as substrate incubated...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of HIV-1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant wild-type p66/p51 HIV-1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type recombinant HIV-1 reverse transcriptase assessed as reduction of biotin-dUTP incorporation into protein using ABTS as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration against HIV-1 wild type reverse transcriptase (IIIB)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as assessed as inhibition of biotin deoxyuridine triphosphate incorporation into proteinMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)More data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of HIV1 RT polymerase K103N mutant by SPAMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against HIV-1 mutant reverse transcriptase (Y181C)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris HCl buffer (25 mL, 60 mm, pH 8.1) cont...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical
Yamanouchi Pharmaceutical
Affinity DataIC50: 21nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical
Yamanouchi Pharmaceutical
Affinity DataIC50: 21nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 22.2nMAssay Description:Inhibitory activity against E138K mutant reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 22.2nMAssay Description:Inhibitory activity against wild-type HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:The reaction mixture was set with template primer complex, RT enzyme and dNTPs in a lysis buffer with or without inhibitors. The reaction mixture was...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 8.1Assay Description:The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant wild type HIV-1 reverse transcriptase using DNA/RNA as substrate incubated for 40 mins by Pico-green dye based spectrofluor...More data for this Ligand-Target Pair
Affinity DataKi: 30nM ΔG°: -44.7kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of HIV-1 wild-type RTMore data for this Ligand-Target Pair