Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 4RET
TargetSodium/potassium-transporting ATPase subunit alpha-4/beta-1(Rat)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant rat Na+/K+-ATPase alpha4/beta1 expressed in baculovirus infected insect Sf9 cell membranes using [gamma-32P]ATP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1(Human)
Universidade Federal De S£O Jo£O Del Rei

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human kidney Na(+)/K(+) ATPase alpha-1 assessed as amount of Pi release after 1 hr by colorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1(Dog)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Na+/K+ ATPase from dog kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1(Dog)
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataIC50: 500nMAssay Description:In vitro inhibitory concentration against dog kidney Na+,K+-ATPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  42.8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  55nMAssay Description:Inhibition of Na,K-ATPase activity of the detergent-soluble α1β1, α2β1, and α3β1 complexes by CGs was done exactly as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  58nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  58.7nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  189nMAssay Description:Inhibition of Na,K-ATPase activity of the detergent-soluble α1β1, α2β1, and α3β1 complexes by CGs was done exactly as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Weizmann Institute of Science

LigandPNGBDBM46355(MLS000069819 | cid_2724385 | SMR000059217 | DIGOXI...)
Affinity DataKi:  268nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)