Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5FBI
TargetComplement factor D [24-253](Human)
Novartis Pharma

LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataIC50: 2.90E+5nMpH: 7.5 T: 2°CAssay Description:Briefly, recombinant human or murine FD catalytic domain (10 nM concentration) were incubated with compound at various concentrations for 1 h at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to 15-N labeled complement factor D (unknown origin) by 1H-15N HSQC NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to recombinant human 15-N labeled complement factor D catalytic domain (G24 to A253 residues) expressed in expressed in Escherichia ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM203867(3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to 15N-labeled human CFD by 1H-15N-HSQC NMR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)