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Target
Complement factor D
Ligand
BDBM203867
Substrate
n/a
Meas. Tech.
ChEMBL_1658834 (CHEMBL4008446)
Kd
1600000±n/a nM
Citation
 Vulpetti, A; Randl, S; Rüdisser, S; Ostermann, N; Erbel, P; Mac Sweeney, A; Zoller, T; Salem, B; Gerhartz, B; Cumin, F; Hommel, U; Dalvit, C; Lorthiois, E; Maibaum, J Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors. J Med Chem 60:1946-1958 (2017) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM203867
Synonyms:
3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic acid (4)
Type:
Small organic molecule
Emp. Form.:
C17H14N2O4
Mol. Mass.:
310.3041
SMILES:
NC(=O)c1cc2cc(OCc3cccc(c3)C(O)=O)ccc2[nH]1
Structure:
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