Report error Found 170 Enz. Inhib. hit(s) for PDB: 5JI0
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Affinity DataEC50: 1nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 1.20nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as thermodynamic dissociation constant by SPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Inhibition of binding to human Retinoic acid receptor RXR DEF domainMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Agonistic activity towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Dissociation constant for binding to Retinoid X receptor gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human PPARgamma expressed in African green monkey COS7 cells assessed as increase in receptor transcriptional activity by lucifer...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Transactivation of human Gal4-fused PPARgamma LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human RXR-beta expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human RXR-alpha expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Effective concentration against Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of [3H]targretin binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Transactivation of GAL4-DBD fused human PPARgamma ligand binding domain expressed in UAS-bla HEL 293H cells preincubated for 16 hrs followed by FRET ...More data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -43.0kJ/molepH: 8.2 T: 2°CAssay Description:Binding assays were performed in 96-well plate format, using a classical filtration assay with a human full length PPARγ construct (GST-PPAR LBD...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation a...More data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPARgamma receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPAR-gamma receptor expressed in Escherichia coli measured after 120 mins by scintillation c...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in human HepG2 cells by transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Agonistic activity towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Dissociation constant for binding to Retinoid X receptor betaMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Agonistic activity towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Transcriptional activation for RXR alpha receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Transcriptional activation of Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Effective concentration against RXR-alpha receptorMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching methodMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Inhibition of [3H]-9-cis-RA binding to human Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of [3H]targretin binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium an...More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibition of [3H]9-cis-RA binding to mouse Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair