Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 5UP0
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 550nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM292797(US10105367, Example 82 | US10376514, Example 82)
Affinity DataIC50: 550nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)