Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 6CZW
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US9896418, Compound 74 | US10597366, Compound 74)
Affinity DataIC50: 55nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US9896418, Compound 74 | US10597366, Compound 74)
Affinity DataIC50: 150nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US9896418, Compound 74 | US10597366, Compound 74)
Affinity DataEC50:  330nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)