Report error Found 119 Enz. Inhib. hit(s) for PDB: 6KQI
Displayed 1 to 50 (of 119 total ) | Next | Last >>
Affinity DataIC50: 0.130nMAssay Description:Inverse agonist activity at human cannabinoid CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation af...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 0.160nMAssay Description:Agonist activity at rat recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataEC50: 0.280nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cells assessed as reversal of forskolin-evoked cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Positive allosteric modulatory activity at C-terminal GFP-tagged human CB1R expressed in HEK293 cell membrane after 90 mins in presence of [3H]CP5594...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay based Tango beta-arrestin recruitment...More data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.437nMAssay Description:Agonist activity at human CB1 receptor expressed in HEK cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Binding assay with hCB1 and hCB2 receptors.More data for this Ligand-Target Pair
Affinity DataKd: 0.5nMAssay Description:Binding affinity to human CB1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]-CP55940 from recombinant human CB1 receptor expressed in CHO cells assessed as inhibition constant incubated for 120 mins by rad...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]CP-55,940 from recombinant human full length CB1 receptor expressed in HEK293 cell membranes after 90 mins by topcount methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.520nMAssay Description:Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Binding affinity to cannabinoid CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor in cell free systemMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Displacement of [3H]-CP55,940 from CB1 receptor in mouse whole brain membranes after 60 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Binding affinity towards cloned human Cannabinoid receptor 1More data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human CB1 receptor transfected in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Agonist activity at recombinant human full length CB1 receptor expressed in HEK293 cell membranes after 2 hrs by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.770nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Displacement of [3H]CP 55940 from human recombinant CB1 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 0.900nMAssay Description:Agonist activity at N-terminal FLAG-tagged human CB1 receptor transfected in human HTLA cells assessed as induction of beta-arrestin-recruitment afte...More data for this Ligand-Target Pair
Affinity DataKd: 0.900nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Displacement of [3H]CP 55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.924nMAssay Description:Binding affinity was determined in vitro against cannabinoid receptor by ability to displace [3H]CP-55940More data for this Ligand-Target Pair
Affinity DataKi: 0.930nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at 3xHA tagged human CB1 receptor expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP accumulation incubate...More data for this Ligand-Target Pair
Affinity DataKd: 1.10nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataKd: 1.20nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataKi: 1.24nMAssay Description:Displacement of [3H]CP-55940 from cannabinoid CB1 receptor in rat brain cortical membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.28nMAssay Description:Displacement of [3H]CP55,940 from human CB1 receptor expressed in CHO cells after 2 hrs by liquid scintillation counterMore data for this Ligand-Target Pair
Affinity DataKd: 1.30nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity to CB1 cannabinoid receptor using [3H]WIN-55212-2 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]CP55,940 from recombinant human CB1 receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.36nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.37nMAssay Description:Binding affinity to human cannabinoid CB1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membranes assessed as increase in G-protein coupling by measuring [35S]GTPgammaS binding...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of [3H]CP-55940 binding to rat cannabinoid receptor 1More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at N-terminal 3HA-tagged human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation mea...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human recombinant CB1 receptor expressed in CHO-K1 cell membrane assessed as increase in GTPgammaS binding pretreated for 30 mins...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]CP-55940 from CD1 mouse brain CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKd: 1.60nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataKd: 1.60nMpH: 7.4Assay Description:Briefly, ~5μg of membranes were incubated at 30 °C for 60 min with [3H]CP55940 (147.9 Ci/mmol; PerkinElmer Life Sciences) or [3H]SR141716A (43 C...More data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liq...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand competitive binding as...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand competitive binding as...More data for this Ligand-Target Pair