Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) for PDB: 6MZW
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant FGFR2 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.60nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.60nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4.90nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)