Report error Found 5 Enz. Inhib. hit(s) for PDB: 6O95
Affinity DataKi: 5.10nMAssay Description:Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate i...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 5.40nMAssay Description:Kinase activities were assayed using the Transcreener-Fluorecescence polarization platform (BelBrook Labs, Madison, Wis., USA) that measures amounts ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase ...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IFN alpha production preincubated for 90 mins followed by R848 stimul...More data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation...More data for this Ligand-Target Pair