Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 7C9I
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 4.30nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 17nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in amyloid beta levels by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 36nMAssay Description:Inhibition of gamma-secretase in cell-free human HeLa membrane assessed as amyloid beta-42 production using APP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 72nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 115nMAssay Description:Inhibition of full-length human gamma secretase expressed in SH-SY5Y spbetaA4CTF cells assessed as reduction in amyloid beta levels after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-secretase subunit PEN-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against gamma-secretase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)