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Found 6 Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit PEN-2'
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50143556((S)-2-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity of the compound against gamma-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100434(CHEMBL302004 | L-68458 | L-685458 | tert-butyl (2S...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration of the compound against gamma-secretase was determinedMore data for this Ligand-Target Pair
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50369830(CHEMBL1790471)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100438(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100435(CHEMBL305152 | [1-(1-Formyl-butylcarbamoyl)-3-meth...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed