Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 7DDI
TargetSodium/potassium-transporting ATPase subunit alpha-1(Dog)
University of Manitoba

Curated by ChEMBL
LigandPNGBDBM46356(SMR000058529 | cid_441207 | MLS000069787 | DIGITOX...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46356(SMR000058529 | cid_441207 | MLS000069787 | DIGITOX...)
Affinity DataKi:  28.8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46356(SMR000058529 | cid_441207 | MLS000069787 | DIGITOX...)
Affinity DataKi:  29.5nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46356(SMR000058529 | cid_441207 | MLS000069787 | DIGITOX...)
Affinity DataKi:  40.7nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Human)
Yeda Research and Development

US Patent
LigandPNGBDBM46356(SMR000058529 | cid_441207 | MLS000069787 | DIGITOX...)
Affinity DataKi:  89nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)