Report error Found 27 Enz. Inhib. hit(s) for PDB: 7Y7W
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter(Rat)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membraneMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter(Rat)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.73E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.75E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.88E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human GAT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter(Rat)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of human GAT1 expresses in tsA201 cells assessed as reduction in [3H]GABA uptake after 3 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich
Curated by ChEMBL
Ludwig Maximilians University At Munich
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich
Curated by ChEMBL
Ludwig Maximilians University At Munich
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GAT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of mouse GTA 1 receptorMore data for this Ligand-Target Pair