Compile Data Set for Download or QSAR
Report error Found 258 of affinity data for UniProtKB/TrEMBL: A6NGA4
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50233990BDBM50233990(CHEMBL4104957)
Affinity DataIC50: 7nMAssay Description:Inhibition of TPH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2019
Entry Details Article
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445676BDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445676BDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Affinity DataIC50: 11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445676BDBM445676(Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...)
Affinity DataIC50: 11nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357737BDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357735BDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50: 14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357737BDBM357737(KM-05-166/(I-206) | US10214530, Example 24)
Affinity DataIC50: 14nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357735BDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357735BDBM357735(KM-05-193/(I-209) | US10214530, Example 27)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445677BDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445677BDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Affinity DataIC50: 14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445677BDBM445677(Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...)
Affinity DataIC50: 14nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445685BDBM445685(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Affinity DataIC50: 15nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445685BDBM445685(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445685BDBM445685(Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...)
Affinity DataIC50: 15nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630639BDBM50630639(CHEMBL5404510)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445694BDBM445694(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Affinity DataIC50: 16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445680BDBM445680(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445694BDBM445694(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Affinity DataIC50: 16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445680BDBM445680(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Affinity DataIC50: 16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445680BDBM445680(Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...)
Affinity DataIC50: 16nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445694BDBM445694(Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445692BDBM445692(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445669BDBM445669(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445669BDBM445669(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445669BDBM445669(Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445672BDBM445672(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445672BDBM445672(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445672BDBM445672(Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445692BDBM445692(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445696BDBM445696(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445696BDBM445696(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Affinity DataIC50: 17nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445692BDBM445692(Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445696BDBM445696(Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445670BDBM445670(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445675BDBM445675(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Affinity DataIC50: 18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445670BDBM445670(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Affinity DataIC50: 18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445670BDBM445670(Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...)
Affinity DataIC50: 18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445675BDBM445675(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445675BDBM445675(Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...)
Affinity DataIC50: 18nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630633BDBM50630633(CHEMBL5438308)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357739BDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445674BDBM445674(Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445666BDBM445666(Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357736BDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357736BDBM357736(MW-01-157/(I-207) | US10214530, Example 25)
Affinity DataIC50: 20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445671BDBM445671(Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445674BDBM445674(Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant MBP-tagged full length human THP2 using L-Trp as substrate assessed as formation of 5-HTP by measuring fluorescent propertyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 357739BDBM357739(AG-01-128/(I-202) | US10214530, Example 18)
Affinity DataIC50: 20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTryptophan 5-hydroxylase 2(Human)
Karos Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 445671BDBM445671(Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...)
Affinity DataIC50: 20nMAssay Description:The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2021
Entry Details
US Patent

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