Compile Data Set for Download or QSAR
Report error Found 168 for UniProtKB: O60894
LigandPNGBDBM50180775([Aib29,Asp31,Pro34,Phe35]CGRP(27-37) | FV-Aib-TDVG...)
Affinity DataKi:  0.00200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50541408(CHEMBL4643140)
Affinity DataKi:  0.00400nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.00500nMAssay Description:Displacement of [125I]CGRP from human cloned CLR/RAMP1 receptor expressed in E10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50180778(FV-Hyp-TDVGPFAF | CHEMBL2371891)
Affinity DataKi:  0.00600nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50541406(CHEMBL4649325)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50541411(CHEMBL4643006)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human CLR/RAMP1 by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50385312(CHEMBL2035984)
Affinity DataKi:  0.0140nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM362044(US9833448, Example 4 | US10272077, Example 4)
Affinity DataKi:  0.0150nMAssay Description:Antagonist activity at human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50385311(CHEMBL2035985)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50062162(FVPTDVGPFAF | CHEMBL264010)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandPNGBDBM50180781(FV-Tic-TDVGPFAF | CHEMBL2371890)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50541407(CHEMBL4638635)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50356282(CHEMBL1910936)
Affinity DataKi:  0.0220nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391727(US10300056, Example 12 | N-[(2R)-1-({(2S)-3-{1-[2-...)
Affinity DataKi:  0.0250nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391727(US10300056, Example 12 | N-[(2R)-1-({(2S)-3-{1-[2-...)
Affinity DataKi:  0.0250nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

LigandPNGBDBM50539955(CHEMBL4638938)
Affinity DataKi:  0.0251nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50385313(CHEMBL2035982)
Affinity DataKi:  0.0280nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0320nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0320nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

LigandPNGBDBM391723(US10300056, Example 8 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391722(US10300056, Example 7 | N-[(2R)-1-({(2S)-3-(1- | U...)
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

LigandPNGBDBM50444982(CHEMBL3099918)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]-hCGRP from human CALCRL/RAMP1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391719(US10300056, Example 4 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391723(US10300056, Example 8 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50385314(CHEMBL2035981)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391722(US10300056, Example 7 | N-[(2R)-1-({(2S)-3-(1- | U...)
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391723(US10300056, Example 8 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0400nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391719(US10300056, Example 4 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0400nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandPNGBDBM50541409(CHEMBL4647045)
Affinity DataIC50: 0.0450nMAssay Description:Inhibition of human CLR/RAMP1 by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50385309(CHEMBL2035983)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50444972(CHEMBL3099931)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-hCGRP from human CALCRL/RAMP1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM103499(US8552023, 11)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-hCGRP from human CALCRL/RAMP1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391725(US10300056, Example 10 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0630nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391720(US10300056, Example 5 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0630nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391725(US10300056, Example 10 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0630nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391720(US10300056, Example 5 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0630nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandPNGBDBM391725(US10300056, Example 10 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM361594(US9833448, Example 1 | US10272077, Example 1)
Affinity DataKi:  0.0670nMAssay Description:Antagonist activity at human CLR/RAMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391724(US10300056, Example 9 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391718(US10300056, Example 3 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0790nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391729(US10300056, Example 14 | 3,5-dibromo-Nalpha-[(2'-o...)
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391718(US10300056, Example 3 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0790nMAssay Description:Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended in the binding buffer (10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

TargetReceptor activity-modifying protein 1(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM391729(US10300056, Example 14 | 3,5-dibromo-Nalpha-[(2'-o...)
Affinity DataKi:  0.0790nMAssay Description:Radioligand binding assay. Human CGRP receptors expressed (consisting of CRLR and RAMP1) in insect Sf21 cell membrane homogenates were re-suspended i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

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