Compile Data Set for Download or QSAR
Report error Found 1379 of affinity data for UniProtKB/TrEMBL: O95819
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788137BDBM788137(b][1,4]oxazin-7-yl)isoquinolin-3-yl)-3- | US124733...)
Affinity DataKi:  0.0600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50548191BDBM50548191(CHEMBL4793665)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human HGK using MBP as substrate assessed as residual activity by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788134BDBM788134(1-Cyclopropyl-3-(7-fluoro-6-(8-methyl- 2,3-dihydro...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788101BDBM788101(7-Azaspiro[3.5]nonan-2-yl (7-fluoro-6- (8-methyl-2...)
Affinity DataKi:  0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788113BDBM788113(2-Azaspiro[3.3]heptan-6-yl (7-fluoro-6- (8-methyl-...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.348nMAssay Description:Inhibition of human HGK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550593BDBM50550593(CHEMBL4746566)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50541592BDBM50541592(CHEMBL3187788)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788112BDBM788112(2-(3-Azabicyclo[3.1.0]hexan-6-yl)ethyl (7-fluoro-6...)
Affinity DataKi:  0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788124BDBM788124(6-Azaspiro[3.4]octan-2-yl (7-fluoro-6- (8-methyl-2...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788127BDBM788127(1-(Cyclopropylmethyl)-3-(7-fluoro-6- (8-methyl-2,3...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human HGK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788120BDBM788120((1R,5S,6s)-3-Azabicyclo[3.1.0]hexan-6- | US1247330...)
Affinity DataKi:  0.580nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550627BDBM50550627(CHEMBL4787152)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788131BDBM788131(1-(Azetidin-3-yl)-3-(7-fluoro-6-(8- methyl-2,3-dih...)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788119BDBM788119(6-(8-methyl-2,3-dihydro-1H- | US12473301, Compound...)
Affinity DataKi:  0.780nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788116BDBM788116((1R,2S)-2-Cyanocyclopentyl (8-chloro- | US12473301...)
Affinity DataKi:  0.805nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788130BDBM788130(1-(7-Fluoro-6-(8-methyl-2,3-dihydro- 1H-pyrido[2,3...)
Affinity DataKi:  0.830nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788132BDBM788132((R)-1-(7-Fluoro-6-(8-methyl-2,3- | US12473301, Com...)
Affinity DataKi:  0.880nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788135BDBM788135((1R,2S,3R)-2-Ethyl-N-(7-fluoro-6-(8- | US12473301,...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788045BDBM788045(1-(Methylcarbamoyl)azetidin-3-yl (7- fluoro-6-(8-m...)
Affinity DataKi:  0.910nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788115BDBM788115(7-fluoro-6-(8-methyl-2,3-dihydro-1H- | US12473301,...)
Affinity DataKi:  0.945nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788125BDBM788125((R)-1-(7-Fluoro-6-(8-methyl-2,3- | US12473301, Com...)
Affinity DataKi:  0.950nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550624BDBM50550624(CHEMBL4759743)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MAP4K4 (unknown origin) incubated for 120 mins in presence of 33P-ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788123BDBM788123(7-Methyl-7-azaspiro[3.5]nonan-2-yl (7- fluoro-6-(4...)
Affinity DataKi:  1.07nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788129BDBM788129(fluoro-6-(8-methyl-2,3-dihydro-1H- | US12473301, C...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788122BDBM788122(2-Methyl-2-azaspiro[3.3]heptan-6-yl (7-fluoro-6-(4...)
Affinity DataKi:  1.15nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550629BDBM50550629(CHEMBL4750540)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50122730BDBM50122730(CHEMBL3623135)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550617BDBM50550617(CHEMBL4781045)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550595BDBM50550595(CHEMBL4783711)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788102BDBM788102(3-Methoxybutyl (7-fluoro-6-(8-methyl- 2,3-dihydro-...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50122742BDBM50122742(CHEMBL3623139)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MAP4K4 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788138BDBM788138((1-methyl-1H-pyrazol-4- | US12473301, Compound 301...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550628BDBM50550628(CHEMBL4740167)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550623BDBM50550623(CHEMBL4779507)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550619BDBM50550619(CHEMBL4787142)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550600BDBM50550600(CHEMBL4745446)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788048BDBM788048(Pyrrolidin-3-ylmethyl (7-fluoro-6-(8- methyl-2,3-d...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 225885BDBM225885(MAP02)
Affinity DataKi:  2.20nM IC50: 5.84nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2017
Entry Details
D3R

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550598BDBM50550598(CHEMBL4751017)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550597BDBM50550597(CHEMBL4757082)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788047BDBM788047((3-Fluoropyrrolidin-3-yl)methyl (7- fluoro-6-(8-me...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788133BDBM788133(dihydro-1H-pyrido[2,3-b][1,4]oxazin-7- | US1247330...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788118BDBM788118((1R,2S)-2-Cyanocyclopentyl (7-fluoro- | US12473301...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 787980BDBM787980(Cyclopropylmethyl (7-fluoro-6-(8- methyl-2,3-dihyd...)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50469353BDBM50469353(CHEMBL4283353)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal GST-tagged HGK (1 to 328 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 788044BDBM788044(1-Acetylazetidin-3-yl (7-fluoro-6-(8- methyl-2,3-d...)
Affinity DataKi:  2.90nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Genentech, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 50550594BDBM50550594(CHEMBL4777705)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
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