Compile Data Set for Download or QSAR
Report error Found 589 of affinity data for UniProtKB/TrEMBL: P00491
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293089(2-Amino-7-{[(1,3-dihydroxypropan-2-yl)amino]methyl...)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293090(2-Amino-7-({[(2R,3S)-1,3,4-trihydroxybutan-2-yl]am...)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(Immucillins, 4 | 7-({[2-hydroxy-1-(hydroxymethyl)e...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(Immucillins, 4 | 7-({[2-hydroxy-1-(hydroxymethyl)e...)
Affinity DataKi:  0.00520nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50135920(2-Amino-7-(3-hydroxy-4-hydroxymethyl-pyrrolidin-1-...)
Affinity DataKi:  0.00680nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human His-tagged PNP assessed as equilibrium dissociation constant by measuring reduction in uric acid formation by spectrophotometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKd:  0.00850nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  0.00860nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246590(7-(((3R,4S)-3-hydroxy-4-(propylthiomethyl)pyrrolid...)
Affinity DataKi:  0.00980nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.0107nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human His-tagged PNP assessed as equilibrium dissociation constant by measuring reduction in uric acid formation by spectrophotometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.0160nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0196nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  0.0290nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046227(2-Amino-6-thiophen-2-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  0.0420nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  0.0420nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0560nMAssay Description:Inhibition of human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046231(2-Amino-6-furan-2-ylmethyl-3,7-dihydro-pyrrolo[3,2...)
Affinity DataIC50: 0.0570nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.0579nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKd:  0.0580nMAssay Description:Binding affinity to human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  0.0660nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046249(2-Amino-6-thiophen-3-ylmethyl-3,7-dihydro-pyrrolo[...)
Affinity DataIC50: 0.0670nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50122726(2-Hydroxymethyl-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyri...)
Affinity DataKi:  0.0720nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046252(2-Amino-6-benzyl-3,7-dihydro-pyrrolo[3,2-d]pyrimid...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046224(2-Amino-8-[(thiophen-3-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50122724(4-Amino-5-(3,4-dihydroxy-5-hydroxymethyl-pyrrolidi...)
Affinity DataKi:  0.0960nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.100nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.104nMAssay Description:Inhibitory activity of compound against human purine nucleoside phosphorylase (PNP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246593(Immucillins, 4 | 7-({[2-hydroxy-1-(hydroxymethyl)e...)
Affinity DataKi:  0.110nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50246590(7-(((3R,4S)-3-hydroxy-4-(propylthiomethyl)pyrrolid...)
Affinity DataKi:  0.117nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM92929(Immucillins, 13)
Affinity DataKd:  0.156nMAssay Description:Inhibition assay using human PNP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2013
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50046246(2-Amino-8-[(thiophen-2-ylmethyl)-amino]-1,9-dihydr...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formation by measuring reduction in uric acid formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50135920(2-Amino-7-(3-hydroxy-4-hydroxymethyl-pyrrolidin-1-...)
Affinity DataKi:  0.163nMAssay Description:Binding affinity towards Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.180nMAssay Description:Dissociation constant against Human Purine Nucleoside Phosphorylase was reportedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50422435(CHEMBL2311112)
Affinity DataKi:  0.180nMAssay Description:Equilibrium dissociation constant determined against human purine nucleoside phosphorylase (PNP) after slow-onset inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
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