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TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.0700nMpH: 7.0Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.200nMpH: 5.5Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50383315(CHEMBL2029773)
Affinity DataKi:  0.400nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50598382(CHEMBL5192083)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  0.900nM IC50: 17.1nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50: 2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50254115(CHEMBL4080589)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of recombinant beta-glucocerebrosidase (unknown origin) using 4-nitrophenyl beta-D-galactopyranoside as substrate pre-incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2019
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50018014(CHEMBL3289676)
Affinity DataKi:  1nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataKi:  1.17nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50099006(7-Diethylamino-2-oxo-2H-chromene-3-carboxylic acid...)
Affinity DataKi:  1.20nMAssay Description:Tested for inhibitory activity against Beta-glucosidase from Agrobacterium speciesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM36514(CID46912122 | MDW933, 5)
Affinity DataKi:  7nM ΔG°:  -48.4kJ/mole IC50: 1.24nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108219(5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H...)
Affinity DataKi:  1.46nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50182801(CHEMBL206468 | AFEGOSTAT TARTRATE | D-Isofagomine ...)
Affinity DataKi:  1.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50182801(CHEMBL206468 | AFEGOSTAT TARTRATE | D-Isofagomine ...)
Affinity DataKi:  1.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50383327(CHEMBL2029772)
Affinity DataKi:  1.80nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108222(2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)...)
Affinity DataKi:  1.93nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM36515(CID46912120 | MDW941, 6)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/mole IC50: 1.94nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2011
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM313450(US10167270, Example 156)
Affinity DataIC50: 1.95nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50: 2.04nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285821(US10081601, Example 3 | (6R,7R,8S)-8-(fluoromethyl...)
Affinity DataKi:  2.10nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285821(US10081601, Example 3 | (6R,7R,8S)-8-(fluoromethyl...)
Affinity DataKi:  2.10nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50100428(6-(5-Dimethylamino-naphthalene-1-sulfonylamino)-he...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50315250((2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol | CHEM...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50315250((2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol | CHEM...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant beta-glucocerebrosidase assessed as p-nitrophenolate accumulation preincubated for 10 mins before p-nitrophenyl-beta-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50100426(5-Dimethylamino-naphthalene-1-sulfonic acid ((3S,4...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285840(US10081601, Example 22 | (6R,7R,8S)-8-(but-1-yn-1-...)
Affinity DataIC50: 2.40nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285840(US10081601, Example 22 | (6R,7R,8S)-8-(but-1-yn-1-...)
Affinity DataIC50: 2.40nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285845(US10081601, Example 27 | (6R,7R,8S)-8-(4-fluorobut...)
Affinity DataIC50: 2.5nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285845(US10081601, Example 27 | (6R,7R,8S)-8-(4-fluorobut...)
Affinity DataIC50: 2.5nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285819(US10081601, Example 1 | (6R,7R,8S)-8-methyl-4-azas...)
Affinity DataKi:  2.60nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285819(US10081601, Example 1 | (6R,7R,8S)-8-methyl-4-azas...)
Affinity DataKi:  2.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataIC50: 2.97nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50383321(CHEMBL2029780)
Affinity DataKi:  3nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  3.06nM IC50: 5.80nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataKi:  3.19nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108223(2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  3.48nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataIC50: 3.62nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108221(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Affinity DataKi:  3.62nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50610369(CHEMBL5277174)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of GCase in patient derived fibroblast cells using 5'pentafluorobenzoylaminofluorescein-di-beta-D-glucoside as substrate assessed as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285819(US10081601, Example 1 | (6R,7R,8S)-8-methyl-4-azas...)
Affinity DataIC50: 3.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM285819(US10081601, Example 1 | (6R,7R,8S)-8-methyl-4-azas...)
Affinity DataIC50: 3.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataIC50: 3.71nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataIC50: 4nMpH: 5.2Assay Description:Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataIC50: 4nMpH: 5.2Assay Description:Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM50383323(CHEMBL2029778)
Affinity DataKi:  4nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108418(US8604206, 14 | US8604206, 13)
Affinity DataKi:  4nM IC50: 7nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetLysosomal acid glucosylceramidase(Human)
University of British Columbia

LigandPNGBDBM108224(N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  4.18nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
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