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TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50507483(CHEMBL4530379)
Affinity DataKi:  0.00230nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50125046(CHEMBL3623792)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of human cationic trypsin using Boc-VPR-MCA as substrate measured every 30 secs for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Compound was tested in vitro for inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50069922(Boropeptide analogue | CHEMBL102069)
Affinity DataKi:  0.0450nMAssay Description:Tested for selectivity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109663(US8609715, A-71)
Affinity DataKi:  0.0540nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234238(US9346821, A-6)
Affinity DataKi:  0.0800nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi:  0.100nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50421510(CHEMBL239127)
Affinity DataKi:  0.100nMAssay Description:Compound was tested for inhibition of Sunflower beta-trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50289586(3-Methyl-2'-sulfamoyl-biphenyl-4-carboxylic acid [...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109651(US8609715, A-59)
Affinity DataKi:  0.120nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109630(US8609715, B-21)
Affinity DataKi:  0.150nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50125045(CHEMBL3623793)
Affinity DataKi:  0.160nMAssay Description:Inhibition of beta-trypsin (unknown origin) using Bz-FVRpNA substrate by spectrophotometry methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetTrypsin(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50533536(CHEMBL4483694)
Affinity DataKi:  0.160nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-FVRpNA as substrate incubated for 30 mins measured for 7 mins by morrison plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193290(US9199927, 1)
Affinity DataIC50: 0.170nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193360(US9199927, 71)
Affinity DataIC50: 0.180nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMAssay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109692(US8609715, B-49)
Affinity DataKi:  0.180nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 uL) was mixed with 20 uM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 uL) mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109629(US8609715, B-20)
Affinity DataKi:  0.180nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158146(US9024044, 74 | US9227949, 74 | US9655879, 74)
Affinity DataKi:  0.180nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL) was mixed with 20 μM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109668(US8609715, B-25)
Affinity DataKi:  0.190nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234247(US9346821, B-14)
Affinity DataKi:  0.190nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.190nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193304(US9199927, 15)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109659(US8609715, A-67)
Affinity DataKi:  0.200nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109710(US8609715, C-4)
Affinity DataKi:  0.200nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109684(US8609715, B-41)
Affinity DataKi:  0.210nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158140(US9024044, 68 | US9227949, 68 | US9655879, 68)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL) was mixed with 20 μM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193313(US9199927, 24)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193369(US9199927, 80)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234250(US9346821, B-20)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158140(US9024044, 68 | US9227949, 68 | US9655879, 68)
Affinity DataKi:  0.210nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 uL) was mixed with 20 uM fluorescence enzyme substrate (Boc-Phe-Ser-Arg-AMC, 50 uL) mixed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193349(US9199927, 108 | US9199927, 60)
Affinity DataIC50: 0.210nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM158140(US9024044, 68 | US9227949, 68 | US9655879, 68)
Affinity DataKi:  0.210nMAssay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2019
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109685(US8609715, B-42)
Affinity DataKi:  0.220nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109622(US8609715, B-8)
Affinity DataKi:  0.220nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193414(US9199927, 96)
Affinity DataIC50: 0.220nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193305(US9199927, 16)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM109660(US8609715, A-68)
Affinity DataKi:  0.230nMAssay Description:Inhibition assay using human trysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193303(US9199927, 14)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193350(US9199927, 61)
Affinity DataIC50: 0.230nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234237(US9346821, A-5)
Affinity DataKi:  0.240nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM234266(US9346821, B-55)
Affinity DataKi:  0.240nMpH: 8.0Assay Description:Using a 96 well plate (#3915, Costar), a test compound (25 μL), 400 mM Tris-HCl buffer (pH 8.0, 25 μL) and 0.5 mg/mL fluorescence enzyme su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50088657(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-((R)-3-i...)
Affinity DataKi:  0.240nMAssay Description:The compound was tested for its ability to inhibit thrombin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193395(US9199927, 113)
Affinity DataIC50: 0.240nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

TargetSerine protease 1(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM193317(US9199927, 28)
Affinity DataIC50: 0.240nMpH: 8.0 T: 2°CAssay Description:The compound was dissolved in dimethyl sulfoxide (DMSO), and diluted to an arbitrary concentration (A). A was 100-fold diluted with a buffer (0.1 M T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2016
Entry Details
US Patent

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