Compile Data Set for Download or QSAR
Report error Found 73 of affinity data for UniProtKB/TrEMBL: P21964
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50019329(CHEMBL1089318)
Affinity DataKi:  1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315227(Isopropyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]th...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315228(Butyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thioph...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315220((2-oxo-1,3-dioxol-4-yl)methyl 3-chloro-5,6-dihydro...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315230(Methyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315221((2-amino-3-methylbutanoyloxy)methyl 3-chloro-5,6-d...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315229(Propyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315226(Benzyl-3-chloro-5,6-dihydroxy-7-nitrobenzo[b]thiop...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315223(Butyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitroben...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315222(1-(Butyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  16.6nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315225(Isobutyryloxymethyl-3-chloro-5,6-dihydroxy-7-nitro...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50315224(1-(Isobutyryloxy)ethyl-3-chloro-5,6-dihydroxy-7-ni...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant COMT by microplate screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086220(CHEMBL3425735)
Affinity DataIC50: 53nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086218(CHEMBL3425740)
Affinity DataIC50: 57nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 61nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086219(CHEMBL3425736)
Affinity DataIC50: 87nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 88nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM206347(US9260413, Example 5)
Affinity DataIC50: 93nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086222(CHEMBL3425732)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086221(CHEMBL3425733)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086223(CHEMBL3425731)
Affinity DataIC50: 160nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  169nMAssay Description:Binding affinity to human COMT incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086217(CHEMBL3425741)
Affinity DataIC50: 180nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM206346(US9260413, Example 1)
Affinity DataIC50: 180nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086214(CHEMBL3425744)
Affinity DataIC50: 200nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM206348(US9260413, Example 6)
Affinity DataIC50: 210nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086234(CHEMBL3425721)
Affinity DataIC50: 400nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086212(CHEMBL3425737)
Affinity DataIC50: 410nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM206349(US9260413, Example 8)
Affinity DataIC50: 590nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086225(CHEMBL3425729)
Affinity DataIC50: 680nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086209(CHEMBL3425722)
Affinity DataIC50: 860nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086218(CHEMBL3425740)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086213(CHEMBL3425734)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086210(CHEMBL3425739)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086211(CHEMBL3425738)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086212(CHEMBL3425737)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086227(CHEMBL3425727)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086217(CHEMBL3425741)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086220(CHEMBL3425735)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086233(CHEMBL3425723)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086228(CHEMBL3425726)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086219(CHEMBL3425736)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086230(CHEMBL3425725)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086231(CHEMBL3425513)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant human membrane bound COMT expressed in Bacmid infected Sf-9 insect cells using dopamine/SAM as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
TargetCatechol O-methyltransferase(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human soluble COMT using dopamine/SAM as substrate/cofactor preincubated for 2 hrs followed by dopamine/SAM addition after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2016
Entry Details Article
PubMed
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