Compile Data Set for Download or QSAR
Report error Found 486 of affinity data for UniProtKB/TrEMBL: P42262
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50457616(CHEMBL4218628)
Affinity DataEC50:  1.26nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50457616(CHEMBL4218628)
Affinity DataEC50:  1.30nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50251236(CHEMBL4091984)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50251236(CHEMBL4091984)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50494356(CHEMBL3088070)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50166288((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Affinity DataKi:  3.89nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50457614(CHEMBL4202524)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50457614(CHEMBL4202524)
Affinity DataEC50:  14.5nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM17662(CHEMBL276815 | 2-amino-3-(3-hydroxy-5-methyl-4-iso...)
Affinity DataKi:  16.8nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50002370((RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-p...)
Affinity DataKi:  17nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 2 (GluR2) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060628((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060630((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191961(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Affinity DataEC50:  32nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191957(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Affinity DataEC50:  36nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191954(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  42nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50251237(CHEMBL4062524)
Affinity DataEC50:  46nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50192216(3-(4-tert-butylphenyl)-4-cyano-5-ethylthiophene-2-...)
Affinity DataEC50:  47nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50164477(CHEMBL3800556)
Affinity DataEC50:  48nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50251237(CHEMBL4062524)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2019
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191954(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  55nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191961(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Affinity DataEC50:  57nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  73nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191952(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Affinity DataEC50:  73nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  73nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50192221(3-(4-tert-butylphenyl)-4-cyano-5-(trifluoromethyl)...)
Affinity DataEC50:  78nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataKi:  80.2nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191952(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Affinity DataEC50:  82nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191957(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Affinity DataEC50:  83nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  97nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-th...)
Affinity DataEC50:  97nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50417574(CHEMBL1642155)
Affinity DataEC50:  100nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50331386(N-((3S,4S)-4-(3'-acetylbiphenyl-4-yl)tetrahydrofur...)
Affinity DataEC50:  100nMAssay Description:Positive modulation of human GluA2 flip receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50417564(CHEMBL1642168)
Affinity DataEC50:  100nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060629((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060636(2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMI...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191955(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Affinity DataEC50:  103nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM17662(CHEMBL276815 | 2-amino-3-(3-hydroxy-5-methyl-4-iso...)
Affinity DataKi:  107nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50027828(3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridi...)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]AMPA from GluA2-S1S2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191948(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Affinity DataEC50:  111nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50060631((S)-2-Amino-3-(5-nitro-2,4-dioxo-3,4-dihydro-2H-py...)
Affinity DataKi:  115nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191956(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  142nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191948(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Affinity DataEC50:  143nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50316375(N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfo...)
Affinity DataEC50:  150nMAssay Description:Activity at human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50094024(propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at GluR2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50164477(CHEMBL3800556)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50417565(CHEMBL1642169)
Affinity DataEC50:  158nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University of Liege

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Displayed 1 to 50 (of 486 total ) | Next | Last >>
Jump to: