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TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 190667BDBM190667(nNOS inhibitor, 5 | US10759791, Compound 14j)
Affinity DataKi:  16nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 152712BDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 190668BDBM190668(nNOS inhibitor, 6 | US10759791, Compound 14k)
Affinity DataKi:  25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50014713BDBM50014713(CHEMBL3262022 | US9951014, Name 6 | US10759791, Co...)
Affinity DataKi:  35nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 190665BDBM190665(nNOS inhibitor, 3 | US10759791, Compound 14g)
Affinity DataKi:  43nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 190666BDBM190666(nNOS inhibitor, 4 | US10759791, Compound 14h)
Affinity DataKi:  72nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50180872BDBM50180872(CHEMBL3819046 | US10759791, Compound 14a)
Affinity DataKi:  139nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50180871BDBM50180871(CHEMBL3819644 | US10759791, Compound 14c)
Affinity DataKi:  547nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50209245BDBM50209245(CHEMBL247378)
Affinity DataIC50: 700nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206065BDBM50206065(N-{2-[1-(3-methoxy-benzyl)-piperidin-4-ylamino]-be...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 8963BDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206073BDBM50206073(N-[2-(2-pyridin-2-yl-ethylamino)-benzothiazol-6-yl...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523390BDBM50523390(CHEMBL4584061)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50365330BDBM50365330(CHEMBL1956107)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of rat recombinant eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206066BDBM50206066(N-(2-{1-[2-(3H-imidazol-4-yl)-ethyl]-piperidin-4-y...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206068BDBM50206068(N-(2-{1-[2-(4-Bromo-phenyl)-ethyl]-piperidin-4-yla...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206070BDBM50206070(N-[2-(2-morpholin-4-yl-ethylamino)-benzothiazol-6-...)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50206064BDBM50206064(N-[2-(1-benzyl-piperidin-4-ylamino)-benzothiazol-6...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of rat endothelial NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523384BDBM50523384(CHEMBL4459416)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523372BDBM50523372(CHEMBL4538398)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523387BDBM50523387(CHEMBL4556281)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523391BDBM50523391(CHEMBL4449083)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523373BDBM50523373(CHEMBL4552440)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523374BDBM50523374(CHEMBL4472570)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523380BDBM50523380(CHEMBL4586157)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523388BDBM50523388(CHEMBL4556575)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523382BDBM50523382(CHEMBL4563209)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523385BDBM50523385(CHEMBL4475391)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523379BDBM50523379(CHEMBL4467355)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523375BDBM50523375(CHEMBL4555818)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523378BDBM50523378(CHEMBL4556372)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523386BDBM50523386(CHEMBL4541558)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523389BDBM50523389(CHEMBL4559477)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523383BDBM50523383(CHEMBL4438120)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50099602BDBM50099602(CHEMBL3343931)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50265253BDBM50265253((S)-2-amino-3-(1H-indol-3-yl)-N-(2-(1,2,3,4-tetrah...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523377BDBM50523377(CHEMBL4559593)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523371BDBM50523371(CHEMBL4456435)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523381BDBM50523381(CHEMBL4444822)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523393BDBM50523393(CHEMBL4466307)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50523392BDBM50523392(CHEMBL4582203)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Rat)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 50379737BDBM50379737(CHEMBL2011128)
Affinity DataIC50: 6.26E+4nMAssay Description:Inhibition of rat eNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed