Compile Data Set for Download or QSAR
Report error Found 9263 of affinity data for UniProtKB/TrEMBL: Q9Y233
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM126829(US8785467, 1-38)
Affinity DataKi:  0.000600nMAssay Description:The activity of the compounds in accordance with the present invention as PDE10 inhibitors may be readily determined without undue experimentation us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641838(CHEMBL5568777)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM47146(US8957073, 4.45 | US8957073, 4.14 | US9718803, 4.4...)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM47146(US8957073, 4.45 | US8957073, 4.14 | US9718803, 4.4...)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM234817(US9353104, 121)
Affinity DataKi:  0.00100nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267012(2-(3-(3-(2,2-dimethyl-3,6- dihydro-2H-pyran-4-yl)p...)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146707(US8957073, 4.41 | US9718803, 4.41)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146672(US8957073, 4.6 | US9718803, 4.6)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146708(US8957073, 4.42)
Affinity DataIC50: 0.00100nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

LigandPNGBDBM234715(US9353104, 3)
Affinity DataKi:  0.00100nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146707(US8957073, 4.41 | US9718803, 4.41)
Affinity DataIC50: 0.00110nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM47146(US8957073, 4.45 | US8957073, 4.14 | US9718803, 4.4...)
Affinity DataIC50: 0.00120nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM47146(US8957073, 4.45 | US8957073, 4.14 | US9718803, 4.4...)
Affinity DataIC50: 0.00120nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM47147(US8957073, 4.44 | US8957073, 4.28 | US9718803, 4.4...)
Affinity DataIC50: 0.00122nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146672(US8957073, 4.6 | US9718803, 4.6)
Affinity DataIC50: 0.00135nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

LigandPNGBDBM194104(US9200001, 18)
Affinity DataKi:  0.00200nMAssay Description:In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM149478(US8975261, I-46)
Affinity DataKi:  0.00200nMAssay Description:In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146667(US8957073, 4.1 | US9718803, 4.1)
Affinity DataIC50: 0.00200nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM194105(US9200001, 19)
Affinity DataKi:  0.00200nMAssay Description:In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
US Patent

LigandPNGBDBM234818(US9353104, 123)
Affinity DataKi:  0.00200nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641839(CHEMBL5542796)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM234819(US9353104, 124)
Affinity DataKi:  0.00200nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146689(US8957073, 4.23 | US9718803, 4.23)
Affinity DataIC50: 0.00200nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM234762(US9353104, 56)
Affinity DataKi:  0.00200nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146687(US8957073, 4.21 | US9718803, 4.21)
Affinity DataIC50: 0.00200nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM234827(US9353104, 132)
Affinity DataKi:  0.00200nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146687(US8957073, 4.21 | US9718803, 4.21)
Affinity DataIC50: 0.00230nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146689(US8957073, 4.23 | US9718803, 4.23)
Affinity DataIC50: 0.00230nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146667(US8957073, 4.1 | US9718803, 4.1)
Affinity DataIC50: 0.00234nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146677(US8957073, 4.11 | US9718803, 4.11)
Affinity DataIC50: 0.00262nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146678(US8957073, 4.12 | US9718803, 4.12)
Affinity DataIC50: 0.00278nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146668(US8957073, 4.2 | US9718803, 4.2)
Affinity DataIC50: 0.00279nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146668(US8957073, 4.2 | US9718803, 4.2)
Affinity DataIC50: 0.00300nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM234726(US9353104, 14)
Affinity DataKi:  0.00300nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641835(CHEMBL5542573)
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM234756(US9353104, 50)
Affinity DataKi:  0.00300nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146678(US8957073, 4.12 | US9718803, 4.12)
Affinity DataIC50: 0.00300nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146677(US8957073, 4.11 | US9718803, 4.11)
Affinity DataIC50: 0.00300nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM194113(US9200001, 28)
Affinity DataKi:  0.00300nMAssay Description:In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641834(CHEMBL5572487)
Affinity DataIC50: 0.00300nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM126842(US8785467, 1-51)
Affinity DataKi:  0.00320nMAssay Description:The activity of the compounds in accordance with the present invention as PDE10 inhibitors may be readily determined without undue experimentation us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2014
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50397973(CHEMBL2180441)
Affinity DataIC50: 0.00330nMAssay Description:Inhibition of PDE10AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146695(US8957073, 4.29 | US9718803, 4.29)
Affinity DataIC50: 0.00350nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146679(US8957073, 4.13 | US9718803, 4.13)
Affinity DataIC50: 0.00376nMT: 2°CAssay Description:Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641837(CHEMBL5562552)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM234825(US9353104, 130)
Affinity DataKi:  0.00400nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP FP kit supplied by Molecular Devices, Sunnyv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50641836(CHEMBL5589788)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of full length human PDE10A incubated for 1 hr by topcount Scintillation plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146679(US8957073, 4.13 | US9718803, 4.13)
Affinity DataIC50: 0.00400nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

LigandPNGBDBM194090(US9200001, 3)
Affinity DataKi:  0.00400nMAssay Description:In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM146688(US8957073, 4.22 | US9718803, 4.22)
Affinity DataIC50: 0.00400nMT: 2°CAssay Description:An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent

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