BindingDB PrimarySearch

Found 51 of affinity data for UniProtKB/TrEMBL: K9N7C7

Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523945(CHEMBL4475926)

Ki: 3.66E+4nMAssay Description:Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523946(ONO-1078)

Ki: 1.27E+5nMAssay Description:Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496959(cmdc.202100576, 23b)

IC50: <1nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496960(cmdc.202100576, 23c)

IC50: <1nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496962(cmdc.202100576, 23e)

IC50: 2nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496961(cmdc.202100576, 23d)

IC50: 2nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496963(cmdc.202100576, 23f)

IC50: 5nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476929(SARS-CoV-2 3CLpro Inhibitors 3a | SARS-CoV-2 3CLpr...)

IC50: 49nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476928(SARS-CoV-2 3CLpro Inhibitors 2a | SARS-CoV-2 3CLpr...)

IC50: 52nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476949(SARS-CoV-2 3CLpro Inhibitors 3k | SARS-CoV-2 3CLpr...)

IC50: 53nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476948(SARS-CoV-2 3CLpro Inhibitors 2k | SARS-CoV-2 3CLpr...)

IC50: 55nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476939(SARS-CoV-2 3CLpro Inhibitors 3f)

IC50: 58nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM476938(SARS-CoV-2 3CLpro Inhibitors 2f)

IC50: 63nMAssay Description:Cloning and Expression of the 3CL Protease of SARS-CoV-2 and FRET Enzyme Assays. The codon-optimized cDNA of full length of 3CLpro of SARS-CoV-2 (Gen...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496949(GC868 | cmdc.202100576, 20b | cmdc.202100576, 20e)

IC50: 300nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458469(CHEMBL4208240)

IC50: 400nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496950(GC867 | cmdc.202100576, 20c)

IC50: 500nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458471(CHEMBL4204431)

IC50: 500nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496951(GC861 | cmdc.202100576, 20d)

IC50: 600nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496949(GC868 | cmdc.202100576, 20b | cmdc.202100576, 20e)

IC50: 600nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458472(CHEMBL4217568)

IC50: 600nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458463(CHEMBL4213159)

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458462(CHEMBL4214066)

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458473(CHEMBL4214471)

IC50: 700nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458470(CHEMBL4209146)

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458465(CHEMBL4203883)

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM496953(GC833 | cmdc.202100576, 20f)

IC50: 700nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair

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3D Structure (crystal)

Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458464(CHEMBL4202812)

IC50: 800nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458466(CHEMBL4208764)

IC50: 900nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM429497(med.21724, Compound 170)

IC50: 6.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458467(CHEMBL4212620)

IC50: 6.10E+3nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50458468(CHEMBL4216101)

IC50: 7.50E+3nMAssay Description:Inhibition of Middle East respiratory syndrome-related coronavirus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523945(CHEMBL4475926)

IC50: 2.00E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM429499(med.21724, Compound 172)

IC50: 2.44E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523946(ONO-1078)

IC50: 2.50E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM429498(med.21724, Compound 171)

IC50: 2.69E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50121025((E)-1-[2,4-Dihydroxy-5-(3-methyl-but-2-enyl)-pheny...)

IC50: 4.21E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50001908(1-(4-Nitro-phenyl)-piperazine | CHEMBL165012)

IC50: 7.16E+4nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM429503(med.21724, Compound 176)

IC50: 1.13E+5nMAssay Description:This is a review article.More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523947(CHEMBL4447423)

IC50: 1.37E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523948(CHEBI:78878 | CHEMBL1743207)

IC50: 1.41E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523949(4-Nitrocatechol | CHEBI:16318)

IC50: 1.45E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50192743(3,4-Dihydroxybenzaldehyde | CHEBI:50205 | Protocat...)

IC50: 2.39E+5nMAssay Description:Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and m...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)

EC50: 1.40E+3nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523944(CHEMBL4544405)

Kd: 7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523946(ONO-1078)

Kd: 1.41E+4nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)

Kd: 7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50384265(CHEMBL2030452)

Kd: 7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523950(CHEMBL1368663)

Kd: 7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50523945(CHEMBL4475926)

Kd: 7.60E+3nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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Replicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
University Of Illinois At Chicago

Curated by ChEMBL

BDBM50192743(3,4-Dihydroxybenzaldehyde | CHEBI:50205 | Protocat...)

Kd: 2.20E+5nMAssay Description:Binding affinity to MERS-CoV papain-like protease by SPR analysisMore data for this Ligand-Target Pair

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