TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKd: 1nMAssay Description:Binding affinity to human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS measured after overnight incubation by fluorescence...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Displacement of 6N-FAM from LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence polariz...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKd: 4.80nMAssay Description:Binding affinity to human apo-form LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS measured after overnight incubation by flu...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 5.30nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as inhibition con...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 12nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 22nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 30nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 31.6nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 34nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 43nMAssay Description:Agonist activity at LRH-1 (unknown origin) transfected in human HeLa cells measured after 24 hrs by Dual Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 56nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 60nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 64nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 70nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 81nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 90nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 100nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Agonist activity at human full length LRH1 transfected in human HeLa cells incubated for 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Agonist activity at LRH-1 (unknown origin) transfected in human HeLa cells measured after 24 hrs by Dual Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as dissociation c...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 150nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 158nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 160nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 200nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 230nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKi: 280nMAssay Description:Displacement of 6N-FAM from human LRH1 LBD (299 to 541 residues) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence p...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 316nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 316nMAssay Description:Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataKd: 320nMAssay Description:Binding affinity to N-terminal 6-His tagged human LRH-1 LBD (299 to 541 residues) expressed in Escherichia coli BL21-(DE3) assessed as dissociation c...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataEC50: 320nMpH: 7.5 T: 2°CAssay Description:The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 5 group A member 2(Human)
Emory University School of Medicine
Curated by ChEMBL
Emory University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of full length LRH1 transfected in HEK293T cells incubated for 20 hrs by luciferase reporter assayMore data for this Ligand-Target Pair






3D Structure (crystal)


































