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TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660616(N-(6-chloropyridin-3-yl)-6- isopropoxyisoquinolin-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660617(N-(6-chloropyridin-3-yl)-6- (cyclopropylmethoxy)is...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660618(N-(6-chloropyridin-3-yl)-6- propoxyisoquinolin-1-a...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660619(N-(6-chloropyridin-3-yl)-6-(2- methoxyethoxy)isoqu...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660620(N-(6-chlorpyridin-3-yl)-6- (pyridin-2- ylmethoxy)i...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660621(N-(6-chloropyridin-3-yl)-6- ((5,5-dimethyltetrahyd...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660622(N-(6-chloropyridin-3-yl)-6- (difluoromethoxy)isoqu...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660623(N-(6-chloropyridin-3-yl)-6- phenoxyisoquinolin-1-a...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660624(N-(2-chloropyrimidin-5-yl)-6- (cyclopropylmethoxy)...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660625(methyl 1-((6-chloropyridin-3- yl)amino)isoquinolin...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660626(N-(6-chloropyridin-3- yl)thieno[3,2-c]pyridin-4- a...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660627(N-(6-chloropyridin-3- yl)thieno[2,3-c]pyridin-7- a...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660628(N-(6-chloropyridin-3- yl)thiazolo[4,5-c]pyridin-4-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660629(N-(6-chloropyridin-3-yl)-1H- pyrrolo[2,3-c]pyridin...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660630(N-(6-chloropyridin-3-yl)-4- methoxy-1H-pyrrolo[2,3...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660631(N-(6-chloropyridin-3- yl)furo[2,3-c]pyridin-7-amin...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660632(N-(6-chloropyridin-3-yl)-3- methylthieno[2,3-c]pyr...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660633(N-(6-chloropyridin-3-yl)-6- fluoroisoquinolin-1-am...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660634(N-(6-chloropyridin-3-yl)-6- methoxyisoquinolin-1-a...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660635(N-(6-chloropyridin-3-yl)-6- methylisoquinolin-1-am...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660636(6-chloro-N-(6-chloropyridin-3- yl)isoquinolin-1-am...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660637(N-(6-chloropyridin-3-yl)-5- fluoroisoquinolin-1-am...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660638(N-(2-chloropyrimidin-5-yl)-6- fluoroisoquinolin-1-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660639(6-(cyclopropylmethoxy)-N-(2- methylpyrimidin-5- yl...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660640(N-(2-methylpyrimidin-5-yl)-6- ((tetrahydrofuran-3-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660641(6-(2,2-difluoroethoxy)-N-(2- methylpyrimidin-5- yl...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660642(6-((5,5- dimethyltetrahydrofuran-2- yl)methoxy)-N-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660643(6-(cyclopropylmethoxy)-N-(6- methylpyridin-3-yl)is...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660644(N-(6-chloropyridin-3-yl)-6-(1- cyclopropylethoxy)i...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660645(N-(6-chloropyridin-3- yl)furo[3,2-c]pyridin-4-amin...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660646(N-(6-chloropyridin-3-yl)-1,7- naphthyridin-8-amine...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660647(N-(2-chloropyimidin-5-yl)-1,7- naphthyridin-8-amin...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660648(N-(6-chloropyridin-3- yl)isoquinolin-1-amine | US2...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660649(((1-((6-chloropyridin-3- yl)amino)isoquinolin-6- y...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660650(N-(6-chloropyridin-3-yl)-4- methyl-1H-pyrrolo[2,3-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660651(Synthesis of N-(6-chloro-5- methoxypyridin-3-yl)-6...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660652(6-(2-methoxyethoxy)-N-(2- methylpyrimidin-5- yl)is...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660653(6-(2-cyclopropoxyethoxy)-N- (2-methylpyrimidin-5- ...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660654(N-(6-chloropyridin-3-yl)-6-(2- cyclopropoxyethoxy)...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660655(3-(((1-((2-chloropyrimidin-5- yl)amino)isoquinolin...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660656(N-(2-chloropyrimidin-5-yl)-6- ((3-isopropyloxetan-...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660657(2-chloro-5-((6-((3- methyloxetan-3- yl)methoxy)iso...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660658(N-(6-(difluoromethyl)pyridin-3- yl)-6-((1- fluoroc...)
Affinity DataEC50: >3.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660659(N-(2-ethylpyrimidin-5-yl)-6- ((1- fluorocyclopropy...)
Affinity DataEC50:  2.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660660(N-(5-chloro-6-methylpyridin-3- yl)-6-((1- fluorocy...)
Affinity DataEC50: >3.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660661(6-((1- fluorocyclopropyl)methoxy)-N- (2-methoxypyr...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660662(6-((1- fluorocyclopropyl)methoxy)-N- (6-(trifluoro...)
Affinity DataEC50: >3.00E+4nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660663(N-(5-chloropyridin-3-yl)-6-((1- fluorocyclopropyl)...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660664(6-((1- fluorocyclopropyl)methoxy)-N- (pyrimidin-5-...)
Affinity DataEC50:  5.50E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660665(4-(((1-((6-chloropyridin-3- yl)amino)isoquinolin-6...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

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