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Report error Found 278 of affinity data for UniProtKB/TrEMBL: P19971
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  1.30nM ΔG°:  -52.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 1.90nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified Escherichia coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50313094(5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | ...)
Affinity DataKi:  17nMAssay Description:Inhibition of human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 19nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50274904(CHEMBL4129617)
Affinity DataIC50: 20nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122764(CHEMBL122679 | 2-Amino-1-(5-bromo-2,6-dioxo-1,2,3,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50531739(MA-1 | TPI (freebase) | Tipiracil)
Affinity DataKi:  20nMAssay Description:Competitive inhibition of thymidine phosphorylase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified Escherichia coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122771(CHEMBL66531 | CHEMBL193667 | 2-Amino-1-(5-chloro-2...)
Affinity DataIC50: 21nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified Escherichia coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 23nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 30nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin) using thymidine as substrate after 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 35nMAssay Description:Inhibitory concentration against human thymidine phosphorylase TPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50531739(MA-1 | TPI (freebase) | Tipiracil)
Affinity DataIC50: 35nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122770(6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-d...)
Affinity DataIC50: 35nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Competitive inhibition of human thymidine phosphorylase in presence of thymidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human placental thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human placenta thymidine phosphorylase using [6-3H]dThd as substrate after 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122771(CHEMBL66531 | CHEMBL193667 | 2-Amino-1-(5-chloro-2...)
Affinity DataIC50: 49nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122768(CHEMBL303346 | CHEMBL194335 | 2-Amino-1-(2,6-dioxo...)
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50464651(CHEMBL4293861)
Affinity DataIC50: 120nMAssay Description:Inhibition of thymidine phosphorylase (unknown origin) using thymidine as substrate after 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50531732(CHEMBL4455140)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human thymidine phosphorylase expressed in Escherichia coli Rosetta (DE3) cells using thymidine as substrate after 1 min by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20061(6-chloro-5-(cyclopent-1-en-1-yl)-1,2,3,4-tetrahydr...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50310199((1-fluoro-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50310200((1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimi...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50310201((1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50310202((2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50201010(((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50310203(8-(5-bromo-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydro...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50201010(((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20069(6-chloro-5-(thiophen-2-yl)-1,2,3,4-tetrahydropyrim...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50443422(CHEMBL3087264)
Affinity DataIC50: 350nMAssay Description:Inhibition of human thymidine phosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20065(6-chloro-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20073(6-chloro-5-[(1E)-pent-1-en-1-yl]-1,2,3,4-tetrahydr...)
Affinity DataKi:  410nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20062(6-chloro-5-(cyclohex-1-en-1-yl)-1,2,3,4-tetrahydro...)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20064(6-chloro-5-[(2E)-pent-2-en-3-yl]-1,2,3,4-tetrahydr...)
Affinity DataKi:  490nM ΔG°:  -37.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20075(6-fluoro-5-phenyl-1,2,3,4-tetrahydropyrimidine-2,4...)
Affinity DataKi:  500nM ΔG°:  -37.4kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50122768(CHEMBL303346 | CHEMBL194335 | 2-Amino-1-(2,6-dioxo...)
Affinity DataIC50: 560nMAssay Description:Compound was evaluated for its inhibitory activity against recombinant purified Escherichia coli Thymidine PhosphorylaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20072(5-[(1E)-but-1-en-1-yl]-6-chloro-1,2,3,4-tetrahydro...)
Affinity DataKi:  630nM ΔG°:  -36.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM20068(6-chloro-5-(4-fluorophenyl)-1,2,3,4-tetrahydropyri...)
Affinity DataKi:  710nM ΔG°:  -36.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetThymidine phosphorylase(Human)
Gilead Sciences

LigandPNGBDBM50117689(Thiophene-2-sulfonic acid [(E)-3-(3',4'-dichloro-b...)
Affinity DataKi:  770nMAssay Description:Inhibitory constant against Prostanoid TP receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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