Compile Data Set for Download or QSAR
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Found 271 of affinity data for UniProtKB/TrEMBL: P19971
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  1.30nM ΔG°:  -52.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards recombinant thymidine phosphorylase TPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50313094(5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | ...)
Affinity DataKi:  17nMAssay Description:Inhibition of human thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50121753(1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human thymidine phosphorylaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50531739(MA-1 | TPI (freebase) | Tipiracil)
Affinity DataKi:  20nMAssay Description:Competitive inhibition of thymidine phosphorylase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against thymidine phosphorylaseMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20079(5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant thymidine phosphorylase by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20061(5-Substituted-6-chlorouracil, 7a | 6-chloro-5-(cyc...)
Affinity DataKi:  200nM ΔG°:  -39.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50310199((1-fluoro-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50310200((1-hydroxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimi...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50310201((1-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50310202((2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201010(((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50310203(8-(5-bromo-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydro...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201010(((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human recombinant thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20069(5-Substituted-6-chlorouracil, 10e | 6-chloro-5-(th...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20065(5-Substituted-6-chlorouracil, 10a | 6-chloro-5-phe...)
Affinity DataKi:  400nM ΔG°:  -38.0kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20073(5-Substituted-6-chlorouracil, 13c | 6-chloro-5-[(1...)
Affinity DataKi:  410nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20062(5-Substituted-6-chlorouracil, 7b | 6-chloro-5-(cyc...)
Affinity DataKi:  420nM ΔG°:  -37.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20064(5-Substituted-6-chlorouracil, 7d | 6-chloro-5-[(2E...)
Affinity DataKi:  490nM ΔG°:  -37.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20075(6-Fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione, 21 |...)
Affinity DataKi:  500nM ΔG°:  -37.4kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20072(5-Substituted-6-chlorouracil, 13b | 5-[(1E)-but-1-...)
Affinity DataKi:  630nM ΔG°:  -36.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20068(5-Substituted-6-chlorouracil, 10d | 6-chloro-5-(4-...)
Affinity DataKi:  710nM ΔG°:  -36.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50117689(CHEMBL87371 | Thiophene-2-sulfonic acid [(E)-3-(3'...)
Affinity DataKi:  770nMAssay Description:Inhibitory constant of the compound was determined against Prostanoid TP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20056(5-Substituted-6-chlorouracil, 5c | 5-butyl-6-chlor...)
Affinity DataKi:  1.03E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201013(((2S,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20059(5-Substituted-6-chlorouracil, 5f | 6-chloro-5-hept...)
Affinity DataKi:  1.06E+3nM ΔG°:  -35.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20071(5-Substituted-6-chlorouracil, 13a | 6-chloro-5-[(1...)
Affinity DataKi:  1.17E+3nM ΔG°:  -35.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20076(6-Bromo-5-phenylpyrimidine-2,4(1H,3H)-dione, 23 | ...)
Affinity DataKi:  1.21E+3nM ΔG°:  -35.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50004462(CHEMBL3233329)
Affinity DataKi:  1.65E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20066(5-Substituted-6-chlorouracil, 10b | 6-chloro-5-(3,...)
Affinity DataKi:  1.74E+3nM ΔG°:  -34.2kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50004460(CHEMBL3233327)
Affinity DataKi:  1.77E+3nMAssay Description:Mixed-type inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli assessed as conversion of thymidide to thymine by Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20058(5-Substituted-6-chlorouracil, 5e | 6-chloro-5-hexy...)
Affinity DataKi:  1.83E+3nM ΔG°:  -34.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50122770(6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory activity against Escherichia coli thymidine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20070(5-Substituted-6-chlorouracil, 10f | 6-chloro-5-(py...)
Affinity DataKi:  3.01E+3nM ΔG°:  -32.8kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20063(5-Substituted-6-chlorouracil, 7c | 6-chloro-5-(pro...)
Affinity DataKi:  3.34E+3nM ΔG°:  -32.5kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20057(5-Substituted-6-chlorouracil, 5d | 6-chloro-5-pent...)
Affinity DataKi:  3.67E+3nM ΔG°:  -32.3kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20067(5-Substituted-6-chlorouracil, 10c | 6-chloro-5-(na...)
Affinity DataKi:  4.59E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20060(5-Substituted-6-chlorouracil, 5g | 5-benzyl-6-chlo...)
Affinity DataKi:  4.65E+3nM ΔG°:  -31.7kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20055(5-Substituted-6-chlorouracil, 5b | 6-chloro-5-prop...)
Affinity DataKi:  5.81E+3nM ΔG°:  -31.1kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201015(((2R,3aR,4R,6R,6aS)-6-(hydroxymethyl)-4-(5-methyl-...)
Affinity DataKi:  8.03E+3nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50439105(CHEMBL2418061)
Affinity DataKi:  1.96E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20054(5-Substituted-6-chlorouracil, 5a | 6-chloro-5-ethy...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20078(6-[(2-Aminoethyl)amino]-5-phenylpyrimidine-2,4(1H,...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20077(5-Phenyl-6-pyrrolidin-1-ylpyrimidine-2,4(1H,3H)-di...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM20074(6-Methyl-5-phenylpyrimidine-2,4(1H,3H)-dione, 16 |...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.9kJ/molepH: 6.4 T: 2°CAssay Description:The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50439106(CHEMBL2418074)
Affinity DataKi:  2.01E+4nMAssay Description:Mixed inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate by Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201012(((2R,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  3.34E+4nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Gilead Sciences

LigandPNGBDBM50201011(2-((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methy...)
Affinity DataKi:  4.35E+4nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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