Compile Data Set for Download or QSAR
Report error Found 1615 for UniProtKB: P25025
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50200880(2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran...)
Affinity DataIC50: 0.0490nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50200878((R)-3-(2-(1-(furan-2-yl)propylamino)-3,4-dioxocycl...)
Affinity DataKd:  0.0490nMAssay Description:Binding affinity to human CXCR2 assessed as dissociation constant incubated for 6 to 24 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50200880(2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5-methylfuran...)
Affinity DataKd:  0.0490nMAssay Description:Displacement of [3H]Sch527123 from human CXCR2 assessed as dissociation constant measured every 30 secs for 48 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50503347(CHEMBL4442431)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CXCR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity at CXCR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255551(CHEMBL4066904)
Affinity DataIC50: 0.158nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255543(CHEMBL4082136)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255536(CHEMBL4098864)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.240nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255490(CHEMBL4060139)
Affinity DataIC50: 0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255548(CHEMBL4072270)
Affinity DataIC50: 0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255564(CHEMBL4062361)
Affinity DataIC50: 0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182266(CHEMBL3818984)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182267(CHEMBL3818853)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182268(CHEMBL3819480)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255537(CHEMBL4077201)
Affinity DataIC50: 0.316nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182274(CHEMBL3819163)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255503(CHEMBL4066818)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182263(CHEMBL3817901)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255553(CHEMBL4070506)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255482(CHEMBL4086957)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182276(CHEMBL3818581)
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182273(CHEMBL3818827)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255484(CHEMBL4103349)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182272(CHEMBL3818277)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255478(CHEMBL4082031)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182265(CHEMBL3819569)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182278(CHEMBL3819221)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182263(CHEMBL3817901)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255541(CHEMBL4088551)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182269(CHEMBL3818793)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255540(CHEMBL4066510)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182251(CHEMBL3819512)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182262(CHEMBL3819295)
Affinity DataIC50: 0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50211457(3-(2-((R)-1-(4-sec-butylfuran-2-yl)propylamino)-3,...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255485(CHEMBL4079102)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182264(CHEMBL3818216)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182255(CHEMBL3818458)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255481(CHEMBL4098979)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255562(CHEMBL4089421)
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182257(CHEMBL3818917)
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182270(CHEMBL3818820)
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50182256(CHEMBL3819542)
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50211449((R)-3-(3,4-dioxo-2-(1-(4-(pentan-3-yl)furan-2-yl)p...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50211454((R)-3-(2-(1-(4-ethylfuran-2-yl)propylamino)-3,4-di...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255544(CHEMBL4076428)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255545(CHEMBL4097602)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50371789(CHEMBL256668)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50169045((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at CXCR2 assessed as inhibition of CXCL8-induced neutrophil chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50255479(CHEMBL4067429)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
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