Compile Data Set for Download or QSAR
Report error Found 2159 of affinity data for UniProtKB/TrEMBL: P40763
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50637323(CHEMBL399894)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632580(CHEMBL5437070)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human Jurkat cells incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50408828(CHEMBL5270588)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of STAT3 (unknown origin) DNA binding activity by EMSAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to STAT3 (127 to 722 residues) (unknown origin) by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to recombinant STAT3 (unknown origin) assessed as inhibition constant incubated for 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588525(CHEMBL5177956)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588528(CHEMBL5209107)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632576(CHEMBL5439447)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632571(CHEMBL5405538)
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514305(CHEMBL4560429)
Affinity DataKi:  7nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3 [702-738,740-752](Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43584(cid_873059 | SMR000093118 | 2-[(1-methyl-2-benzimi...)
Affinity DataIC50: 8.49nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632570(CHEMBL5433451)
Affinity DataIC50: 9nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of STAT3 phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514302(CHEMBL4452527)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant STAT3 (unknown origin) assessed as inhibition constant incubated for 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514306(CHEMBL4471887)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50620353(CHEMBL5404765)
Affinity DataIC50: 13nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588530(CHEMBL5201151)
Affinity DataIC50: 13nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50519537(CHEMBL4469750)
Affinity DataIC50: 13nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514303(CHEMBL4443339)
Affinity DataKi:  14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514299(CHEMBL4515406)
Affinity DataKi:  14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514297(CHEMBL4575382)
Affinity DataKi:  14nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50530395(CHEMBL4444178)
Affinity DataIC50: 15nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50620343(CHEMBL5395308)
Affinity DataIC50: 17nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 18nMAssay Description:Inhibition of IFN-alpha induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IFN-alpha stimulation and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588531(CHEMBL5171007)
Affinity DataIC50: 20nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataIC50: 20nMAssay Description:Inhibition of IL-23 stimulated STAT3 production in human naive T cell preincubated with compound for 10 to 15 mins followed by IL-23 stimulation and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588525(CHEMBL5177956)
Affinity DataKd:  21nMAssay Description:Binding affinity to human recombinant STAT3 expressed in Escherichia coli BL21 by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588507(CHEMBL5178622)
Affinity DataIC50: 22nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50: 23nMAssay Description:Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635143(CHEMBL5558267)
Affinity DataIC50: 23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514298(CHEMBL4571181)
Affinity DataKi:  25nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3 [702-738,740-752](Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43688(SMR000146251 | MLS000552736 | (E)-2-(1H-Benzoimida...)
Affinity DataEC50: >25.5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
TargetSignal transducer and activator of transcription 3 [702-738,740-752](Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43560(SMR000066913 | cid_2115839 | 4-ethanoyl-N-(2-metho...)
Affinity DataIC50: 25.5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM515659(US11053219, Example 28 | BDBM515661 | US11053219, ...)
Affinity DataIC50: 28nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKd:  28nMAssay Description:Binding affinity to human recombinant STAT3 assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588526(CHEMBL5189135)
Affinity DataIC50: 28nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50569086(CHEMBL4868479)
Affinity DataKd:  29nMAssay Description:Binding affinity to His-tagged STAT3-SH2 domain (127 to 722 residues) (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50632573(CHEMBL5428659)
Affinity DataIC50: 29nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50635167(CHEMBL5555159)
Affinity DataIC50: 29nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588514(CHEMBL5184385)
Affinity DataIC50: 31nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590921(CHEMBL5176948)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50: 33nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-6 stimulation and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50514296(CHEMBL4443240)
Affinity DataKi:  33nMAssay Description:Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50343634(4-((E)-4-((S)-1-((1R,2S,5S)-2-((S)-5-amino-1-(benz...)
Affinity DataKi:  33nMAssay Description:Binding affinity to SH2 domain of Stat3 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50602483(CHEMBL5175648)
Affinity DataKd:  34nMAssay Description:Binding affinity to recombinant GST tagged STAT3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50612060(CHEMBL5279856)
Affinity DataIC50: 35nMAssay Description:Inhibition of STAT3 phosphorylation a in human MOLM16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50588527(CHEMBL5201419)
Affinity DataIC50: 36nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590882(CHEMBL5182844)
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50620351(CHEMBL5405344)
Affinity DataIC50: 38nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in HEK-Blue IL-6 cells incubated for 20 to 24 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Displayed 1 to 50 (of 2159 total ) | Next | Last >>
Jump to: