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Report error Found 278 of affinity data for UniProtKB/TrEMBL: P42858
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578375BDBM50578375(CHEMBL4875017)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578380BDBM50578380(CHEMBL4878942)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578376BDBM50578376(CHEMBL4863336)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578377BDBM50578377(CHEMBL4847156)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578378BDBM50578378(CHEMBL4867927)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50578379BDBM50578379(CHEMBL4859053)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595435BDBM50595435(CHEMBL5179682)
Affinity DataIC50: 8nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595435BDBM50595435(CHEMBL5179682)
Affinity DataIC50: 8nMAssay Description:Inhibition of HTT (unknown origin) by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595433BDBM50595433(CHEMBL5195936)
Affinity DataIC50: 40nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595433BDBM50595433(CHEMBL5195936)
Affinity DataIC50: 40nMAssay Description:Inhibition of HTT (unknown origin) by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595434BDBM50595434(CHEMBL5175104)
Affinity DataIC50: 80nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595434BDBM50595434(CHEMBL5175104)
Affinity DataIC50: 80nMAssay Description:Inhibition of HTT (unknown origin) by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405603BDBM50405603(CHEMBL5288592)
Affinity DataKd:  100nMAssay Description:Binding affinity to mutant HTT (unknown origin) mediated HD exon 1-72Q aggregation assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50085415BDBM50085415(G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...)
Affinity DataKd:  100nMAssay Description:Binding affinity to mutant HTT (unknown origin) mediated HD exon 1-72Q aggregation assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96500BDBM96500(cid_7497069 | MLS001157845 | N'-[(1E)-1-(1-cyclohe...)
Affinity DataIC50: 450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96499BDBM96499(cid_5928270 | MLS001158344 | N'-[(1Z)-1-[1-cyclohe...)
Affinity DataIC50: 452nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96534BDBM96534(SMR001282215 | N-(5-chloranylthiophen-2-yl)sulfony...)
Affinity DataIC50: 462nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96471BDBM96471(methyl 3-[(2E)-2-(1-cyano-2-oxo-2-phenylethylidene...)
Affinity DataIC50: 561nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 64759BDBM64759(3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(6-methyl-1,3...)
Affinity DataIC50: 624nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 58741BDBM58741(methyl 2-[4-hydroxy-3-(5-methylfuran-2-carbonyl)-2...)
Affinity DataIC50: 636nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50256BDBM50256(cid_1595371 | (5E)-1-butyl-5-[(E)-3-(furan-2-yl)pr...)
Affinity DataIC50: 721nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 48867BDBM48867((5Z)-4-methyl-5-[[5-(4-methyl-2-nitrophenyl)furan-...)
Affinity DataIC50: 784nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96419BDBM96419(6-chloranyl-N-[2-(2-chlorophenyl)ethyl]-5-methyl-7...)
Affinity DataIC50: 796nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 53725BDBM53725(N-[(5Z)-5-[(4,5-dimethoxy-2-nitrophenyl)methyliden...)
Affinity DataIC50: 848nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 90877BDBM90877(MLS001199048 | cid_16012569 | 3-[(3-fluorobenzoyl)...)
Affinity DataIC50: 859nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 53935BDBM53935(4-methyl-N-[(5Z)-4-oxo-5-(phenylmethylene)-2-thiaz...)
Affinity DataIC50: 879nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 61891BDBM61891(cid_3152768 | 1-(6-chloro-1,3-benzothiazol-2-yl)-2...)
Affinity DataIC50: 987nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96413BDBM96413(SMR000066316 | 6-(2-furanyl)-3-methyl-1-phenyl-4-p...)
Affinity DataIC50: 1.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96462BDBM96462(MLS000516399 | 2-[(6E)-6-[(4-methoxyphenyl)methyli...)
Affinity DataIC50: 1.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 70228BDBM70228(3-[5-[(Z)-(5-imino-7-oxo-3-propan-2-ylsulfonyl-[1,...)
Affinity DataIC50: 1.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 54149BDBM54149(cid_2807878 | 5-thiophen-3-yl-3-[[4-(trifluorometh...)
Affinity DataIC50: 1.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 46036BDBM46036(2-[[3-(3-oxidanylidene-1,2-benzothiazol-2-yl)pheny...)
Affinity DataIC50: 1.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 46215BDBM46215(2-[4-[[5-(4-chlorophenyl)-7-methyl-3-oxo-6-[oxo(pr...)
Affinity DataIC50: 1.11E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96446BDBM96446(SMR000260936 | MLS000391903 | cid_2318621)
Affinity DataIC50: 1.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60895BDBM60895(4-[[3-[(5Z)-5-(2-furanylmethylidene)-4-oxo-2-sulfa...)
Affinity DataIC50: 1.18E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 75042BDBM75042((6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(methyls...)
Affinity DataIC50: 1.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 66209BDBM66209(3-(1-benzofuran-2-ylcarbonyl)-2-(3-chlorophenyl)-1...)
Affinity DataIC50: 1.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50430741BDBM50430741(CHEMBL2333942)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HD exon 1 fusion protein with 51 glutamine residues (unknown origin) aggregation expressed in Escherichia coli SURE after 16 hrs by Wes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96523BDBM96523(sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-a...)
Affinity DataIC50: 1.21E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96424BDBM96424(5-(butylcarbamoyl)-3-(naphthalen-1-ylsulfanylmethy...)
Affinity DataIC50: 1.21E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96519BDBM96519(MLS002252338 | cid_2381372 | 4-chloro-2-[[2-[4-[(4...)
Affinity DataIC50: 1.24E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96417BDBM96417(5-(4-methylnaphthalen-1-yl)-N-(4-methylphenyl)sulf...)
Affinity DataIC50: 1.34E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96537BDBM96537(1-[1-(4-chlorophenyl)cyclobutanecarbonyl]-2-methyl...)
Affinity DataIC50: 1.37E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96536BDBM96536(N-[3-[bis(fluoranyl)methoxy]phenyl]sulfonyl-2-[4-(...)
Affinity DataIC50: 1.45E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 61059BDBM61059(MLS000592167 | 2-[5-(2,5-dichlorophenyl)furan-2-yl...)
Affinity DataIC50: 1.47E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96507BDBM96507(MLS001147241 | 4,5-dimethoxy-2-[[[4-[methyl(phenyl...)
Affinity DataIC50: 1.48E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96472BDBM96472(SMR000459203 | cid_2818390 | MLS000859024 | 1-(phe...)
Affinity DataIC50: 1.52E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 53765BDBM53765(MLS000540062 | cid_5433630 | 6-[2-[[(Z)-(3-methyl-...)
Affinity DataIC50: 1.54E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 96412BDBM96412(cid_2354951 | 2-[(2,5-dimethylphenyl)sulfonylamino...)
Affinity DataIC50: 1.55E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
TargetHuntingtin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 76195BDBM76195(N'-(2-bromo-1-methylcyclopropanecarbonyl)-6-oxopyr...)
Affinity DataIC50: 1.59E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2013
Entry Details
PCBioAssay
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