Compile Data Set for Download or QSAR
Report error Found 1917 for UniProtKB: P47869
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50259814(CHEMBL4062225)
Affinity DataEC50:  118nMAssay Description:Modulation of recombinant human GABA alpha2beta3gamma2 receptor expressed in HEK293 cells assessed as change in GABA-induced current at -80 mV holdin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2020
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50459889(CHEMBL4224740)
Affinity DataEC50:  7.60E+3nMAssay Description:Positive allosteric modulation of recombinant wild type GABAA receptor alpha2beta2gamma2S (unknown origin) expressed in HEK293 cells assessed as pote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM246487(Batatasin III (4) | US20240398793, Compound 8)
Affinity DataEC50:  8.08E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of EC3 to 10 GABA-induc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497208(CHEMBL3289196)
Affinity DataEC50:  1.48E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50497206(CHEMBL3289195)
Affinity DataEC50:  2.64E+4nMAssay Description:Modulation of GABAA alpha2beta2gamma2S receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as modulation of GABA-induced chloride ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50100943(3-Amino-propane-1-selenic acid | CHEMBL41065)
Affinity DataEC50:  1.50E+6nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50032955(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | CH...)
Affinity DataEC50:  5.00E+4nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50100946(piperidine-4-seleninic acid | Piperidine-4-selenic...)
Affinity DataEC50:  1.70E+5nMAssay Description:Effective dose for agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50087272(CHEMBL34155 | P4S | Piperidine-4-sulfonic acid | P...)
Affinity DataEC50:  2.60E+4nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50100944(Piperidin-4-yl-phosphinic acid | CHEMBL291079)
Affinity DataEC50:  2.80E+5nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50000106(Piperidine-4-carboxylic acid | Piperidine-4-carbox...)
Affinity DataEC50:  4.20E+5nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM85712(1H-imidazol-4-ylacetic acid | NSC_96215 | CAS_645-...)
Affinity DataEC50:  6.00E+5nMAssay Description:Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120774(2-(2-Fluoro-phenyl)-8-(4-methoxy-benzoyl)-6,7,8,9-...)
Affinity DataEC50:  383nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120777(8-(3-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  70nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001728(CHEMBL661 | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]t...)
Affinity DataEC50:  12nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120772(2-(2-Fluoro-phenyl)-8-propionyl-6,7,8,9-tetrahydro...)
Affinity DataEC50:  110nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM26266(Ambien | CHEMBL911 | ZPM | N,N-dimethyl-2-[6-methy...)
Affinity DataEC50:  737nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120789(8-Benzyl-2-(4-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  245nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120801(2-(2-Fluoro-phenyl)-8-pyrimidin-2-yl-6,7,8,9-tetra...)
Affinity DataEC50:  84nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120779(8-(4-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  55nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120782(2-(2-Fluoro-phenyl)-8-pyridin-3-ylmethyl-6,7,8,9-t...)
Affinity DataEC50:  101nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120792(8-Benzyl-2-p-tolyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-...)
Affinity DataEC50:  1.18E+3nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120775(2-(2-Fluoro-phenyl)-8-pyridin-4-ylmethyl-6,7,8,9-t...)
Affinity DataEC50:  99nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120771(8-Benzyl-2-(2-thiophen-2-yl-phenyl)-6,7,8,9-tetrah...)
Affinity DataEC50:  879nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120805(2-(2-Fluoro-phenyl)-8-propenyl-6,7,8,9-tetrahydro-...)
Affinity DataEC50:  284nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120790(8-Benzyl-2-(2,5-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Affinity DataEC50:  188nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120799(8-(3,4-Difluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8...)
Affinity DataEC50:  238nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120781(8-Benzyl-2-(3-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  154nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120794(2-(2-Fluoro-phenyl)-8-thiophen-2-ylmethyl-6,7,8,9-...)
Affinity DataEC50:  67nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120812(8-Benzyl-2-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  143nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120788(8-Butyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H-...)
Affinity DataEC50:  247nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120808(2-(2-Fluoro-phenyl)-8-(4-methyl-benzoyl)-6,7,8,9-t...)
Affinity DataEC50:  327nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120786(8-Benzyl-2-(3-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Affinity DataEC50:  268nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120773(8-(2-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Affinity DataEC50:  256nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120798(2-(2-Fluoro-phenyl)-8-(3H-imidazol-4-ylmethyl)-6,7...)
Affinity DataEC50:  459nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120783(8-Benzyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Affinity DataEC50:  20nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120795(2-(2-Fluoro-phenyl)-8-(2-methyl-benzoyl)-6,7,8,9-t...)
Affinity DataEC50:  134nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120793(8-Cyclopropylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-te...)
Affinity DataEC50:  1.16E+3nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120791(8-Cyclohexylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-tet...)
Affinity DataEC50:  202nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120809(8-Benzyl-2-phenyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-t...)
Affinity DataEC50:  184nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120776(8-Benzyl-2-(2,4-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Affinity DataEC50:  210nMAssay Description:Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataEC50:  35nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-carbazole-3-carboxylic ac...)
Affinity DataEC50:  14nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50332376(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Affinity DataEC50:  104nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50332375(4-Amino-8-(5-(azetidine-1-carbonyl)pyridin-3-yl)-N...)
Affinity DataEC50:  54nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50332374(9-Amino-2-cyclobutyl-5-(pyrimidin-2-yl)-2,3-dihydr...)
Affinity DataEC50:  34nMAssay Description:Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50060088(2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Affinity DataEC50:  1.30E+9nMAssay Description:Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
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