Compile Data Set for Download or QSAR
Report error Found 2005 of affinity data for UniProtKB/TrEMBL: P48067
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202275(US9238619, 33)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202315(US9238619, 51)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202314(US9238619, 50)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202316(US9238619, 52)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202341(US9238619, 63)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202337(US9238619, 62)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202334(US9238619, 59)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202336(US9238619, 61)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202335(US9238619, 60)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50277866(2,4-dichloro-N-((3-(cyclopropylmethyl)-1-(1-methyl...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202241(US9238619, 6)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202353(US9238619, 72)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202240(US9238619, 5)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202356(US9238619, 73)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202348(US9238619, 67)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202239(US9238619, 4)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202351(US9238619, 70)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202238(US9238619, 3)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202247(US9238619, 10)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202359(US9238619, 76)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202358(US9238619, 75)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202249(US9238619, 12)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202361(US9238619, 78)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202266(US9238619, 24)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202265(US9238619, 23)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202260(US9238619, 18)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202272(US9238619, 30)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202271(US9238619, 29)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202274(US9238619, 32)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202273(US9238619, 31)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202270(US9238619, 28)
Affinity DataKi: <0.100nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50277942(2,4-dichloro-N-((3-(3-fluoropyridin-2-yl)-1-(1-met...)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50149871((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50178415((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50277943(2,4-dichloro-N-((4-(3-fluoropyridin-2-yl)-1-(1-met...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of [3H]glycine uptake at human glycine transporter 1 expressed in human JAR cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50533742(CHEMBL4593786)
Affinity DataIC50: 0.671nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50533732(CHEMBL4526580)
Affinity DataIC50: 0.726nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50533748(CHEMBL4468117)
Affinity DataIC50: 0.733nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50126022({[3-(Biphenyl-4-yloxy)-3-(4-fluoro-phenyl)-propyl]...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity towards rat hippocampus GlyT1 transporter expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50368757(CHEMBL4169829)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50368698(CHEMBL4161906)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50368693(CHEMBL4171521)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]N-Methyl-SSR504734 from human GlyT1c expressed in cell membranes incubated for 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM327829(2-((R)-4-((S)-(3-bromophenyl)(phenyl)methyl)-2-met...)
Affinity DataIC50: 0.934nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50178423(2-((2-(4,5-dichloro-2-(4-fluorophenyl)-6-methoxy-1...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM327832(2-((R)-2-methyl-4-((R)-phenyl(3-(trifluoromethyl)p...)
Affinity DataIC50: 0.980nMAssay Description:This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202283(US9238619, 37)
Affinity DataKi: <1nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202276(US9238619, 34)
Affinity DataKi: <1nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50460356(CHEMBL4224734)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM202282(US9238619, 36)
Affinity DataKi: <1nMAssay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details
US Patent

TargetSodium- and chloride-dependent glycine transporter 1(Human)
Abbvie Deutschland

US Patent
LigandPNGBDBM50460357(CHEMBL4226364)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human GlyT1 expressed in CHO cells assessed as reduction in [3H]glycine uptake pretreated for 15 mins followed by [3H]glyci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Displayed 1 to 50 (of 2005 total ) | Next | Last >>
Jump to: