TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.0617nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.123nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.155nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.155nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.162nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.224nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.234nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.302nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.316nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.316nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.355nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.389nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.513nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 0.540nMAssay Description:Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesiclesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.562nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.661nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.676nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.676nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.851nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 0.871nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of Rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 1.20nM ΔG°: -52.5kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 2nM ΔG°: -51.1kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 2.30nM ΔG°: -50.8kJ/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp
Curated by ChEMBL
University Of Antwerp
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Rh£Ne-Poulenc Rorer Central Research
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair