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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473181(US10844038, Example 28 | trans 3-((4-Amino-3-pheny...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473182(US10844038, Example 30 | trans 3-((4-Amino-3-(4-ch...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473183(US10844038, Example 36 B. | (3R,4R)-3-((4-amino-3-...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473176(US10844038, Example 38 | trans 1-((4-Methoxy-1,2-d...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473176(US10844038, Example 38 | trans 1-((4-Methoxy-1,2-d...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473178(US10844038, Example 40 | trans 1-((4-(Benzyloxy)-1...)
Affinity DataKd:  52nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473174(US10844038, Example 43 A. | (3S,4R)-3-((4-amino-3-...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473171(US10844038, Example 43 B. | (3R,4S)-3-((4-amino-3-...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473175(US10844038, Example 46 A. | (3S,4S)-3-((4-amino-3-...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM473172(US10844038, Example 46 B. | (3R,4R)-3-((4-amino-3-...)
Affinity DataKd: <5nMAssay Description:Kd: For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
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TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50257128(CHEMBL4087906)
Affinity DataKd:  1.30E+3nMAssay Description:Inhibition of partial length human MEK5 expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50268010(CHEMBL4098896)
Affinity DataKd:  88nMAssay Description:Binding affinity to partial length human MEK5 expressed in HEK293 cells by active-site-dependent competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  38nMAssay Description:Binding affinity to human MEK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50532781(CHEMBL4571241)
Affinity DataKd:  38nMAssay Description:Binding affinity to human MEK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM6511(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4...)
Affinity DataKd:  430nMAssay Description:Binding affinity to human wild type partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50605511(CHEMBL5193786)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to wild type human partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system by Kinomescan binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50621890(CHEMBL5415503)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to MEK5 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50651192(CHEMBL5633837)
Affinity DataKd:  6.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)
Affinity DataKd:  124nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  0.888nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  5.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50342916(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((2-methyl...)
Affinity DataKd:  47nMAssay Description:Binding affinity to human Mek5 More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  1.80nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  2.90nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  7nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  75nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  360nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  190nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  200nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKd:  3.10E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50355499(CHEMBL1908395 | CHEMBL1908842 | US20250129067, Com...)
Affinity DataKd:  99nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  32nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for MEK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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