Compile Data Set for Download or QSAR
Report error Found 155 of affinity data for UniProtKB/TrEMBL: Q14012
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545573(CHEMBL4635883 | US11530193, Example 54)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CAMK1A using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545576(CHEMBL4640712 | US11530193, Example 50)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CAMK1A using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human CAMK1a using KKALRRQETVDAL as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CAMK1A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human CAMK1A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataKi: <10nMAssay Description:Inhibition of wild-type human full length CAMK1A (M1 to L370 residues) expressed in bacterial expression system assessed as residual activity at 50 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  27nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  27nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  27nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  30nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  130nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  130nMAssay Description:Binding affinity to CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  230nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  470nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  970nMAssay Description:Binding affinity to CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  970nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  970nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  970nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CAMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50571440(CHEMBL4873571)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human CaMK1 (2 to end residues) using calmodulin as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CAMK1alpha preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  1.10E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  1.40E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  1.60E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.68E+3nMAssay Description:Inhibition of CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataKd:  1.90E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  2.00E+3nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  2.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataKd:  2.10E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd:  2.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50222913(4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-p...)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50563780(CHEMBL4795714)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of wild-type human CAMK1alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.00E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  3.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of CAMK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50024294(SP-600125)
Affinity DataKd:  4.10E+3nMAssay Description:Average Binding Constant for CAMK1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50440018(CHEMBL2425628)
Affinity DataKd:  4.30E+3nMAssay Description:Binding affinity to CAMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataKd:  4.70E+3nMAssay Description:Binding constant for CAMK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding constant for full-length CAMK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50425008(CHEMBL2312185)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CAMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
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