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Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559281(CHEMBL4748354)

IC50: 10nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50446982(CHEMBL3116050)

IC50: 12nMAssay Description:Inhibition of Jak2 in mouse BA/F3 cells expressing TEL-Jak2 assessed as inhibition of STAT5 phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559282(CHEMBL4759953)

IC50: 13nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559292(CHEMBL4756422)

IC50: 25nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559284(CHEMBL4753549)

IC50: 41nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559293(CHEMBL4789273)

IC50: 51nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559275(CHEMBL4798378)

IC50: 58nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559295(CHEMBL4741075)

IC50: 61nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50122318(BMS-911543)

IC50: 65nMAssay Description:Inhibition of JAK2 in mouse BAF3 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559290(CHEMBL4741668)

IC50: 76nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559294(CHEMBL4776245)

IC50: 120nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559286(CHEMBL4760274)

IC50: 128nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50505817(CHEMBL4447631)

IC50: 145nMAssay Description:Inhibition of JAK2 V617F mutant in BAF3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559288(CHEMBL4756516)

IC50: 145nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50505817(CHEMBL4447631)

IC50: 145nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559276(CHEMBL4791651)

IC50: 177nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559270(CHEMBL4754686)

IC50: 234nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559289(CHEMBL4789556)

IC50: 287nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559272(CHEMBL4749454)

IC50: 302nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559271(CHEMBL4790747)

IC50: 354nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559260(CHEMBL4758253)

IC50: 365nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559264(CHEMBL4753147)

IC50: 392nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559269(CHEMBL4745529)

IC50: 420nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559259(CHEMBL4747449)

IC50: 431nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559268(CHEMBL4745971)

IC50: 445nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559274(CHEMBL4748445)

IC50: 452nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559273(CHEMBL4739994)

IC50: 640nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559261(CHEMBL4740411)

IC50: 679nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559277(CHEMBL4795467)

IC50: 695nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559267(CHEMBL4778749)

IC50: 760nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559283(CHEMBL4743195)

IC50: 784nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50426599(CHEMBL2325898)

IC50: 850nMAssay Description:Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric a...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559278(CHEMBL4776686)

IC50: 908nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559280(CHEMBL4763560)

IC50: 938nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50210177(ONX-0803 | Pacritinib | SB-1518 | SB1518)

IC50: 1.06E+3nMAssay Description:Inhibition of JAK2 V617F mutant in BAF3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50426601(CHEMBL2325895)

IC50: 1.10E+3nMAssay Description:Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric a...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559287(CHEMBL4757237)

IC50: 1.20E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559265(CHEMBL4741778)

IC50: 1.21E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559291(CHEMBL4744166)

IC50: 1.43E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559263(CHEMBL4778029)

IC50: 1.89E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)

IC50: 2.04E+3nMAssay Description:Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric a...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559262(CHEMBL4760064)

IC50: 2.18E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559258(CHEMBL4789489)

IC50: 2.33E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559285(CHEMBL4777006)

IC50: 2.48E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559266(CHEMBL4744889)

IC50: 2.57E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
West China Hospital Of Sichuan University

Curated by ChEMBL

BDBM50559257(CHEMBL4793696)

IC50: 4.39E+3nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Tyrosine-protein kinase JAK2(Mus musculus)
Astrazeneca

Curated by ChEMBL

BDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)

EC50: 186nMAssay Description:Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair

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