TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: 0.00400nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.0623nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: <0.100nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: <0.100nMAssay Description:Activation of human STING (139 to 379 residues) expressed in THP1-Blue ISG cells incubated for 24 hrs by quanti-blue SEAP reporter gene assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKi: 0.190nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Affinity DataKd: 0.195nMAssay Description:Compounds were analyzed on an 5200 biacore SPR instrument (GE Healthcare). E.coli produced truncated STING protein was immobilized on a series S stre...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.200nMAssay Description:Binding affinity to human STING (137 to 379 residues) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.200nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.280nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.280nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.300nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:A radioligand binding assay was developed to determine whether compound interactions were competitive with a tritium-labeled version of the native ST...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.300nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: 0.354nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.440nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
Affinity DataKd: 0.5nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.780nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataKd: 0.789nMAssay Description:Binding affinity to His-tagged wild type human STING C-terminal domain (149 to 379 residues) expressed in Escherichia coli BL21 (DE3) cells assessed ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataEC50: <1nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataEC50: <1nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonist activity at STING in human PBMC cells assessed as increase in IFNp by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human PBMC cells assessed as increase in IFNp by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataEC50: <1nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Korea Research Institute of Chemical Technology
Curated by ChEMBL
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human PBMC cells assessed as increase in IFNp by electrochemiluminescence assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair

































3D Structure (crystal)






