Compile Data Set for Download or QSAR
Report error Found 1633 for UniProtKB: Q8NBP7
LigandChemical structure of BindingDB Monomer ID 50581548BDBM50581548(CHEMBL5085124)
Affinity DataKi:  0.000600nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581547BDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.000930nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581546BDBM50581546(CHEMBL5084416)
Affinity DataKi:  0.00239nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581547BDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.00736nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581545BDBM50581545(CHEMBL5084902)
Affinity DataKi:  0.00813nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581544BDBM50581544(CHEMBL5086475)
Affinity DataKi:  0.00826nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581544BDBM50581544(CHEMBL5086475)
Affinity DataKi:  0.00940nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581548BDBM50581548(CHEMBL5085124)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581546BDBM50581546(CHEMBL5084416)
Affinity DataKi:  0.0114nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581549BDBM50581549(CHEMBL5082483)
Affinity DataKi:  0.0370nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581544BDBM50581544(CHEMBL5086475)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581545BDBM50581545(CHEMBL5084902)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581546BDBM50581546(CHEMBL5084416)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581547BDBM50581547(CHEMBL5081349)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581548BDBM50581548(CHEMBL5085124)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50565590BDBM50565590(CHEMBL4780905)
Affinity DataEC50:  0.150nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50543439BDBM50543439(CHEMBL4642977)
Affinity DataIC50: 0.152nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581542BDBM50581542(CHEMBL5081587)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581542BDBM50581542(CHEMBL5081587)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581540BDBM50581540(CHEMBL5087487)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581537BDBM50581537(CHEMBL5086286)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50565595BDBM50565595(CHEMBL4785006)
Affinity DataEC50:  0.280nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50609097BDBM50609097(CHEMBL5271747)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human PCSK9More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50543440BDBM50543440(CHEMBL4635142)
Affinity DataIC50: 0.327nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581535BDBM50581535(CHEMBL5091040)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581537BDBM50581537(CHEMBL5086286)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50543441BDBM50543441(CHEMBL4642595)
Affinity DataIC50: 0.438nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581540BDBM50581540(CHEMBL5087487)
Affinity DataKi:  0.450nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581535BDBM50581535(CHEMBL5091040)
Affinity DataKi:  0.480nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50543444BDBM50543444(CHEMBL4641251)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50565596BDBM50565596(CHEMBL4797870)
Affinity DataEC50:  0.690nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782791BDBM782791(6-(6-(((1S,3S)-3-((5-(2,2,2-trifluoroethoxyl)pyrim...)
Affinity DataKd:  0.800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 50543442BDBM50543442(CHEMBL4645450)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50543443BDBM50543443(CHEMBL4638184)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of human PCSK9 by Alexa Fluor 647 staining based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782795BDBM782795(US20250326722, Example 132)
Affinity DataKd:  1.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 782797BDBM782797(6-(6-(((1S,3S)-3-((7-(trifluoromethyl)-[1,2,4]tria...)
Affinity DataKd:  1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 782794BDBM782794(6-(6-(((1S,3S)-3-((7-methyl-[1,2,4]triazolo[1,5-a]...)
Affinity DataKd:  1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 50581543BDBM50581543(CHEMBL5094648)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50565591BDBM50565591(CHEMBL4783308)
Affinity DataEC50:  1.20nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782792BDBM782792(6-(6-(((1S,3S)-3-((6-cyclopropyl-1,2,4-triazin-3-y...)
Affinity DataKd:  1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 782800BDBM782800(2-(6-(((1S,3S)-3-((7-fluoro-[1,2,4]triazolo[1,5-a]...)
Affinity DataKd:  1.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 50554754BDBM50554754(CHEMBL4790764)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50554754BDBM50554754(CHEMBL4790764)
Affinity DataKi:  1.40nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782785BDBM782785(6-(6-(((1S,3S)-3-((5-(difluoromethoxy)pyrimidin-2-...)
Affinity DataKd:  1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 50554734BDBM50554734(CHEMBL4761415 | US11530244, Compound 289)
Affinity DataKi:  1.5nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50554755BDBM50554755(CHEMBL4782157)
Affinity DataKi:  1.5nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782793BDBM782793(6-(6-(((1S,3S)-3-((5-cyclopropylpyrimidin-2-yl)ami...)
Affinity DataKd:  1.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

LigandChemical structure of BindingDB Monomer ID 50554743BDBM50554743(CHEMBL4759174)
Affinity DataKi:  2.10nMAssay Description:Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50581539BDBM50581539(CHEMBL5084586)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 782790BDBM782790(6-(6-(((1S,3S)-3-((5-(trifluoromethoxy)pyrimidin-2...)
Affinity DataKd:  2.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details US Patent

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