BDBM50581547 CHEMBL5081349

SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3[C@@H]4CCN3C(=O)[C@@H]3Cc5cn(Cc6cn(nn6)-c6cc(CSCCNC(=O)[C@]7(C)CCCN7C2=O)cc(CSCCC(=O)N[C@@H](C)C(=O)N[C@H](CNC(=O)CCOCCOCC[N+](C)(C)C)C(=O)N[C@@H](Cc2cccc(C\C=C\CO4)c2)C(=O)N3)c6)c2ccc(F)cc52)[C@@H](C)O)cc1

InChI Key InChIKey=SLOOASDFBYIJAG-FILUIVIOSA-O

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50581547   

TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.000930nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.00736nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction in OATP 1B1-mediated [3H]-pitavastatin uptake preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed