Compile Data Set for Download or QSAR
Report error Found 1404 of affinity data for UniProtKB/TrEMBL: Q92633
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251697(US9464060, 33 | US10100018, Example 33)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251697(US9464060, 33 | US10100018, Example 33)
Affinity DataIC50: 0.300nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at 37 degC by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251681(US9464060, 17 | US10100018, Example 17)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251696(US9464060, 32 | US10100018, Example 32)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251697(US9464060, 33 | US10100018, Example 33)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251681(US9464060, 17 | US10100018, Example 17)
Affinity DataIC50: 0.400nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.490nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs at room temperature by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  0.740nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754501(1-(5-cyanopyridin-2-yl)-N-(2-(difluoromethoxy)-6-m...)
Affinity DataIC50: 1nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251682(US9464060, 18 | US10100018, Example 18)
Affinity DataIC50: 1nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251682(US9464060, 18 | US10100018, Example 18)
Affinity DataIC50: 1nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251680(US9464060, 16 | US10100018, Example 16)
Affinity DataIC50: 1nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251681(US9464060, 17 | US10100018, Example 17)
Affinity DataIC50: 1nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754489(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-1-(4-...)
Affinity DataIC50: 1nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754300(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-3-(2-...)
Affinity DataIC50: 1.30nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754495(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-1-(5-...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251678(US9464060, 14 | US10100018, Example 14)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754637(1-(2-(1H-tetrazol-1-yl)acetyl)-N-(2-(difluorometho...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754507(1-(5-cyanopyrimidin-2-yl)-N-(2-(difluoromethoxy)-6...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754699(N-(5-bromo-3-(difluoromethoxy)pyridin-2-yl)-3-(2-i...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754696(N-(5-chloro-3-(difluoromethoxy)pyridin-2-yl)-3-(2-...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251696(US9464060, 32 | US10100018, Example 32)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251696(US9464060, 32 | US10100018, Example 32)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754419(1-(2-(3-((2-(difluoromethoxy)-6-methylpyridin-3-yl...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754483(methyl 1-(5-(3-((2-(difluoromethoxy)-6-methylpyrid...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251678(US9464060, 14 | US10100018, Example 14)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754492(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-1-(3-...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251678(US9464060, 14 | US10100018, Example 14)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251682(US9464060, 18 | US10100018, Example 18)
Affinity DataIC50: 2nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754327(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-3-(2-...)
Affinity DataIC50: 2nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to recombinant human LPA1 expressed in CHO cell membranes measured after 0.5 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM654367(Preparation of (R)-1-(2,5-difluoropyridin-3-yl)eth...)
Affinity DataEC50:  2.90nMAssay Description:CHO-K1 EDG2 cells (DiscoverX cat #93-0644C2) expressing human LPAR1 (NM_001401.3) were seeded in a total volume of 25 μL of Dulbecco's Modif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754709(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-3-(3-...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251677(US9464060, 13 | US10100018, Example 13)
Affinity DataIC50: 3nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L-α-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754317((R)-N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-1...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754347(ethyl-3-(4-((2-(difluoromethoxy)-6-methylpyridin-3...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754714(N3-(5-bromo-3-(difluoromethoxy)pyridin-2-yl)-N1-cy...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754537(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-3-(2-...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754711(N3-(5-chloro-3-(difluoromethoxy)pyridin-2-yl)-N1-c...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754534(N-(2-(difluoromethoxy)-6-methylpyridin-3-yl)-1-(5-...)
Affinity DataIC50: 3nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195700(CHEMBL3975893)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as reduction in LPA-induced intracellular Ca2+ concentration pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754309(N-(6-ethoxy-2-methoxypyridin-3-yl)-3-(2-isopropylp...)
Affinity DataIC50: 4nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM251695(US9464060, 31 | US10100018, Example 31)
Affinity DataIC50: 4nMT: 2°CAssay Description:Engagement of the LPA1 receptor by its ligand, oleoyl-L- ±-lysophosphatidic acid (LPA), leads to the release of intracellular stores of calcium into ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754340(1-(2-cyanoethyl)-N-(2-(difluoromethoxy)-6-methylpy...)
Affinity DataIC50: 4nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM754306(N-(2,6-dimethoxypyridin-3-yl)-3-(2-isopropylphenyl...)
Affinity DataIC50: 4nMAssay Description:The Tango™ EDG2-bla U2OS cells are obtained from Invitrogen. These cells contain the human LPA1 receptor cDNA linked to a TEV protease site and a Gal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Displayed 1 to 50 (of 1404 total ) | Next | Last >>
Jump to: