Compile Data Set for Download or QSAR
Report error Found 612 of affinity data for UniProtKB/TrEMBL: Q99640
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506980BDBM50506980(CHEMBL4583196 | US20250340886, Compound A10)
Affinity DataKi:  0.5nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataKi:  0.800nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752413BDBM752413(US20250197405, Compound 12-P2)
Affinity DataIC50: 1.5nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752408BDBM752408(US20250197405, Compound 7)
Affinity DataIC50: 1.5nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752406BDBM752406(US20250197405, Compound 6-P1)
Affinity DataIC50: 1.80nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataKi:  2nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataKi:  2nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataKi:  2nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752400BDBM752400(US20250197405, Compound 1-P1)
Affinity DataIC50: 2.10nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752412BDBM752412(US20250197405, Compound 11)
Affinity DataIC50: 2.30nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4213BDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4213BDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  2.30nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752410BDBM752410(US20250197405, Compound 9)
Affinity DataIC50: 2.80nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598830BDBM50598830(CHEMBL5186220)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752399BDBM752399(US20250197405, Compound 1)
Affinity DataIC50: 3nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598832BDBM50598832(CHEMBL5185146)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598833BDBM50598833(CHEMBL5181222)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598836BDBM50598836(CHEMBL5190822)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598835BDBM50598835(CHEMBL5169345)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752411BDBM752411(US20250197405, Compound 10)
Affinity DataIC50: 3.40nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752405BDBM752405(US20250197405, Compound 5-P1)
Affinity DataIC50: 3.90nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598834BDBM50598834(CHEMBL5198360)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598838BDBM50598838(CHEMBL5172086)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752404BDBM752404(US20250197405, Compound 4)
Affinity DataIC50: 4.10nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598831BDBM50598831(CHEMBL5195417)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598820BDBM50598820(CHEMBL5191665)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598855BDBM50598855(CHEMBL5190904 | US20240207300, Compound 116 | US12...)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598837BDBM50598837(CHEMBL5187022)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598840BDBM50598840(CHEMBL5199806)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598839BDBM50598839(CHEMBL5184178)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13216BDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506980BDBM50506980(CHEMBL4583196 | US20250340886, Compound A10)
Affinity DataIC50: 6nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598841BDBM50598841(CHEMBL5196095)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataIC50: 7nMAssay Description:Competitive inhibition of human Myt1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598856BDBM50598856(CHEMBL5174072 | US20240207300, Compound 201 | US12...)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  7.30nMAssay Description:Binding affinity to human PKMYT1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataIC50: 8nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 3096BDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598822BDBM50598822(CHEMBL5177087)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598810BDBM50598810(CHEMBL5202826)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598842BDBM50598842(CHEMBL5176413)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4213BDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4213BDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4213BDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50598851BDBM50598851(CHEMBL5199076 | US20240207300, Compound 292)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of recombinant human GST-tagged PKMYT1 (75 to 362 residues) expressed in insect cells using GTDEGIYDVPLLG as substrate preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752402BDBM752402(US20250197405, Compound 2)
Affinity DataIC50: 8.90nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 737398BDBM737398(US20250136596, Example 127)
Affinity DataIC50: 10nMAssay Description:Compound serial dilution is performed by Echo, and the final concentrations vary from 10 μM to 0.5 nM. This was filled by the addition of 5 μL/well o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 737397BDBM737397(US20250136596, Example 126)
Affinity DataIC50: 10nMAssay Description:Compound serial dilution is performed by Echo, and the final concentrations vary from 10 μM to 0.5 nM. This was filled by the addition of 5 μL/well o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

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