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TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 347454BDBM347454(MO-OH-TM | US9790158, 5)
Affinity DataKi:  0.0400nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50123957BDBM50123957(5-(4-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoi...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366693BDBM50366693(CHEMBL1793812)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1/11/4/6/8(Human)
Orchid Chemicals & Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 65470BDBM65470(Quinolone-based HDAC inhibitor 4i)
Affinity DataIC50: 0.100nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50646089BDBM50646089(CHEMBL5595114)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of HDAC8 (unknown origin) using Ac-Leu-Gly-Lys(tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 347452BDBM347452(MO-OH-SM | US9790158, 3)
Affinity DataKi:  0.140nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774932BDBM774932((E)-3-(5-(((1-(6- Cyano-5'-(3- hydroxy-4- methoxyp...)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 347330BDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.170nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218940BDBM50218940(CHEMBL1793991)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366696BDBM50366696(CHEMBL1793811)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366738BDBM50366738(CHEMBL1793985)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50238632BDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human recombinant HDAC8 by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774883BDBM774883((E)-3-(5-(((1-(4-(4- cyano-3-fluorophenyl)- 3-(cya...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774925BDBM774925((E)-3'-Cyano-5'- (3-hydroxy-4- methoxyphenyl)- 2'-...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774725BDBM774725(7-((2-(4-aminopiperidin-1-yl)-6-(4-cyano-3-fluorop...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774922BDBM774922((E)-3-(4-(((1-(3- Cyano-4-(5- cyanopyrazin-2- yl)-...)
Affinity DataIC50: 0.260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774934BDBM774934((E)-3-(4-(((1-(6-Cyano- 3'-fluoro-5'-(3-hydroxy- 4...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366712BDBM50366712(CHEMBL1793822)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774938BDBM774938(((E)-3-(4-(((1-(6-Cyano-5'-(3-hydroxy-4-methoxyphe...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50588302BDBM50588302(CHEMBL5199116)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774924BDBM774924((E)-3-(4-(((1- (3',6-Dicyano-5'- (3-hydroxy-4- met...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774919BDBM774919(Methyl (E)-3'- cyano-5'-(3- hydroxy-4- methoxyphen...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50588303BDBM50588303(CHEMBL5170036)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774936BDBM774936((E)-3-(4-(((1-(6-Cyano- 3'-fluoro-5'-(2-fluoro-5- ...)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774929BDBM774929((E)-3-(4-(((1-(6- Cyano-5'-(3- hydroxy-4- methoxyp...)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50650841BDBM50650841(CHEMBL98245)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human recombinant HDAC8 by ELISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366713BDBM50366713(CHEMBL1793816)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774920BDBM774920((E)-3-(4-(((1-(6- Cyano-5'-(3- hydroxy-4- methoxyp...)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50515971BDBM50515971(CHEMBL4441774)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 347453BDBM347453(MO-OH-DM | US9790158, 4)
Affinity DataKi:  0.440nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774931BDBM774931((E)-3-(4-(((1-(6- Cyano-5'-(2-fluoro- 5-hydroxy-4-...)
Affinity DataIC50: 0.450nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50105327BDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 347330BDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.530nMAssay Description:Competitive inhibition of human recombinant HDAC8 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774923BDBM774923((E)-3-(4-(((1- (3',6-Dicyano-5'- (3-hydroxy-4- met...)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774917BDBM774917((E)-3-(4-(((1-(3'- Cyano-6- (difluoromethyl)- 5'-(...)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774928BDBM774928((E)-3-(4-(((1-(6- Cyano-5'-(2- fluoro-5- hydroxy-4...)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774827BDBM774827((E)-3-(4-(((1-(3- Cyano-4-(4- cyano-3- fluoropheny...)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774914BDBM774914((E)-3-(4-(((1-(3'- Cyano-5'-(3- hydroxy-4- methoxy...)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774921BDBM774921((E)-3-(4-(((1- (3',6-Dicyano-5'- (2-fluoro-5- hydr...)
Affinity DataIC50: 0.680nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774790BDBM774790((E)-3-(4-((1-(3- Cyano-4-(4- cyanophenyl)-5- (3-hy...)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774926BDBM774926((Z)-3-(4-(((1- (3',6-Dicyano-5'- (3-hydroxy-4- met...)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50534338BDBM50534338(CHEMBL4534486)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human recombinant HDAC8 using H2N-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate after 90 mins by fluorescence based micro plate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50650840BDBM50650840(CHEMBL5632276)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HDAC8 (unknown origin) assessed as release of fluorogenic AMC pre-incubated for 15 mins followed by addition of trypsin and substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774789BDBM774789((E)-3-(5-((1-(3- Cyano-4-(4- cyano-3- fluorophenyl...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50534338BDBM50534338(CHEMBL4534486)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorophore-conjugated substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774937BDBM774937((Z)-3-(4-(((1-(6-Cyano- 3'-fluoro-5'-(3-hydroxy- 4...)
Affinity DataIC50: 0.830nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774915BDBM774915((E)-3-(4-(((1- (3',6-Dicyano-5- fluoro-5'-(3- hydr...)
Affinity DataIC50: 0.860nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774815BDBM774815((E)-3-(4-(((1-(4- (4-Cyano-3- fluorophenyl)-5- (3-...)
Affinity DataIC50: 0.860nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774913BDBM774913((E)-3-(4-(((1- (3',6-Dicyano-5'- (3-hydroxy-4- met...)
Affinity DataIC50: 0.870nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

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