PMID

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Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity.

Tokyo Institute of Innovative Research

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

University of Texas Southwestern Medical Center

Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.

Eisai

Development of inhibitors of the PAS-B domain of the HIF-2a transcription factor.

University of Texas Southwestern Medical Center

Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.

National Cancer Institute-Frederick

Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2a induced gene expression.

Nci-Frederick

Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer.

Therachem Research Medilab

3-[(1

Peloton Therapeutics

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1? Inhibition.

Duke University

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

Kyoto University

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.

University of Southampton Faculty of Medicine

Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.

University of Mississippi

Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.

Emory University Csi

Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway.

Georgia State University

Mitochondrial respiration inhibitors suppress protein translation and hypoxic signaling via the hyperphosphorylation and inactivation of translation initiation factor eIF2? and elongation factor eEF2.

University of Mississippi

Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.

Emory University School of Medicine

Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration.

University of Mississippi

Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells.

University of Mississippi

The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

University of Mississippi

Lipophilic 2,5-disubstituted pyrroles from the marine sponge Mycale sp. inhibit mitochondrial respiration and HIF-1 activation.

University of Mississippi

Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells.

University of Mississippi

Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.

Saic-Frederick

Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species.

Korean Research Institute of Biosciences and Biotechnology

Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells.

Korea Research Institute of Bioscience and Biotechnology

Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

University of Mississippi

Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells.

University of Mississippi

Molecular-targeted antitumor agents: the Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1.

University of Mississippi

Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.

University of Louisana

Hypoxia-inducible factor-1 and nuclear factor-kappaB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia.

Korea Research Institute of Bioscience and Biotechnology

Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway.

University of Utah

Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.

University of Mississippi

Benzochromenones from the marine crinoid Comantheria rotula inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays and differentially suppress the growth of certain tumor cell lines.

University of Mississippi

Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.

Korean Research Institute of Biosciences and Biotechnology

(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.

Korea Research Institute of Bioscience and Biotechnology

Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells.

University of Mississippi

Design and Activity of Specific Hypoxia-Inducible Factor-2? (HIF-2?) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

Peloton Therapeutics