BDBM50009714 CHEMBL191::{2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-3H-imidazol-4-yl}-methanol(DuP 753)
SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InChI Key InChIKey=JGABCUJSSAEYFF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 52 hits for monomerid = 50009714
Affinity DataKi: 3.60nMAssay Description:Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptorMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Binding affinity expressed as inhibitory concentration against angiotensin II of rat adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Binding affinity against angiotensin II receptor in rat smooth muscle cell preparationsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro binding affinity of the compound for angiotensin II AT1 receptor in rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro binding affinity of the compound for angiotensin II AT2 receptor in rat midbrainMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+4nMAssay Description:In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without usi...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membran...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+4nMAssay Description:Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]-angiotensin II binding to rat uterine ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]-angiotensin II binding to rat uterine m...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro antagonistic activity by displacement of [125I]-Sar1-Ile8-A II at the rat adrenal cortical aorta Angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of the compound against human angiotensin II receptor, type 1 (AG2-R)More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Binding affinity for rat angiotensin II receptor, type 1More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabit aortic strip contractionMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Displacement of [125I]angiotensin-2 from bovine adrenal cortex AT1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [125-I]-labeled angiotensin II binding to AT1 receptor in rat uterine membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 350nMAssay Description:Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of [125l]-All binding to bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Binding affinity for angiotensin II receptor of bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 MMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Tested for binding affinity against angiotensin II receptor in bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Binding affinity of the compound expressed as inhibitory concentration towards bovine adrenal cortex angiotensin II receptor was measuredMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:In vitro binding affinity to angiotensin II receptor in bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+5nMAssay Description:Concentration required for 50% inhibition of binding against Angiotensin II receptor in the bovine adrenal cortex tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 425nMAssay Description:Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex mem...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Displacement of [125I]Ang2 from AT1 receptor in bovine adrenal cortexMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 8.20E+4nMAssay Description:Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:In vitro Angiotensin II receptor antagonist activity in rat adrenal cortex tissue.More data for this Ligand-Target Pair