BDBM50012957 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea::1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea::5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide::5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide::CHEMBL472::GLYBURIDE::Glibenclamide
SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI Key InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 50012957
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataKi: 660nMAssay Description:Binding affinity to PPARgamma (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 6(Rattus norvegicus)
Kyoto University Hospital
Curated by ChEMBL
Kyoto University Hospital
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University
Curated by ChEMBL
West Virginia University
Curated by ChEMBL
Affinity DataKi: 1.67E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
Affinity DataKi: 6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in membrane vesicles from Bsep-expressing Sf9 cellsMore data for this Ligand-Target Pair
TargetSolute carrier family 15 member 2(Rattus norvegicus)
Kyoto University Hospital
Curated by ChEMBL
Kyoto University Hospital
Curated by ChEMBL
Affinity DataKi: 7.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetSolute carrier family 15 member 1(Rattus norvegicus)
Kyoto University Hospital
Curated by ChEMBL
Kyoto University Hospital
Curated by ChEMBL
Affinity DataKi: 2.50E+4nMAssay Description:TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.75E+4nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake(Glibenclamide 30uM, 50 % of control) in membrane vesicles prepared from High Five cells infected wi...More data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Oryctolagus cuniculus)
Al-Zaytoonah Private University of Jordan
Curated by ChEMBL
Al-Zaytoonah Private University of Jordan
Curated by ChEMBL
Affinity DataIC50: 2.39E+5nMAssay Description:Inhibition of CETP in rabbit serum after 1 hr by fluorescent cholesteryl esters transfer assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
University Joseph Fourier-Grenoble 1/CNRS
Curated by ChEMBL
University Joseph Fourier-Grenoble 1/CNRS
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of wild type CFTR expressed in CHO cells by [125I]iodide efflux assayMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Bologna
Curated by ChEMBL
University of Bologna
Curated by ChEMBL
Affinity DataIC50: 7.40E+4nMAssay Description:K+ channel blocking activity in neuroblastoma cells expressing HERG Kv11.1More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Compound was tested for the inhibition of beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+5nMAssay Description:Compound was tested for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of malate dehydrogenase (MDH)More data for this Ligand-Target Pair
Affinity DataIC50: 1.57E+4nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 1 uM) in liver canalicular membrane vesicle from female ratMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 1 uM) in liver canalicular membrane vesicle from male ratMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hospital for Sick Children
Curated by ChEMBL
Hospital for Sick Children
Curated by ChEMBL
Affinity DataIC50: 1.50E+5nMAssay Description:TP_TRANSPORTER: inhibition of mitoxantrone efflux in BCRP-expressing MCF7-MX cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+5nMAssay Description:TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Bologna
Curated by ChEMBL
University of Bologna
Curated by ChEMBL
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of human ERG potassium channelMore data for this Ligand-Target Pair
TargetATP synthase subunit gamma, mitochondrial(Bos taurus)
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
The Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration towards rat mitochondrial F1F0 ATP hydrolase using a pyruvate kinase / lactate dehydrogenase systemMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Bologna
Curated by ChEMBL
University of Bologna
Curated by ChEMBL
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University
Curated by ChEMBL
West Virginia University
Curated by ChEMBL
Affinity DataIC50: 3.91E+4nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse bone marrow derived macrophages preincubated for 15 mins followed by addition of ATP ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
The University of Manchester
Curated by ChEMBL
The University of Manchester
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of NLRP3 in LPS activated human monocytes after 30 mins by ELISA analysis in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol-Myers Squibb Co.
Curated by ChEMBL
Bristol-Myers Squibb Co.
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estrone-3-sulfate substrateMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol-Myers Squibb Co.
Curated by ChEMBL
Bristol-Myers Squibb Co.
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using pitavastatin substrateMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol-Myers Squibb Co.
Curated by ChEMBL
Bristol-Myers Squibb Co.
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estradiol-17beta-glucuronide substrateMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Hospital for Sick Children
Curated by ChEMBL
Hospital for Sick Children
Curated by ChEMBL
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human MCF7/MX cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level prein...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Bologna
Curated by ChEMBL
University of Bologna
Curated by ChEMBL
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology
Korea Institute of Science and Technology
Affinity DataEC50: 6.40E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair