BDBM50138663 2-naphthimidamide::CHEMBL105171::Naphthalene-2-carboxamidine::uPa_6

SMILES NC(=N)c1ccc2ccccc2c1

InChI Key InChIKey=URXJHZXEUUFNKM-UHFFFAOYSA-N

Data  13 KI

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50138663   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.90E+3nMAssay Description:Binding affinity towards Urokinase-type plasminogen activator (urokinase)More data for this Ligand-Target Pair
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.91E+3nMAssay Description:Photometric_Method1More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.91E+3nMAssay Description:Binding affinity to human urokinase-type plasminogen activator (microPa).More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.91E+3nM ΔG°:  -7.13kcal/molepH: 7.4 T: 2°CAssay Description:Abbott uPA__Urokinase Human - Ki(uM)More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  6.31E+3nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  7.78E+3nMAssay Description:Binding affinity against porcine trypsin was determined.More data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  7.80E+3nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
TargetPlasma kallikrein(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  2.25E+4nMAssay Description:Binding affinity against human plasma kallikrein.More data for this Ligand-Target Pair
TargetKallikrein-1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  2.30E+4nMAssay Description:Binding affinity towards P-kallikreinMore data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.10E+4nMAssay Description:Binding affinity against plasminMore data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi:  5.13E+4nMAssay Description:Binding affinity towards human plasmin.More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards tissue type plasminogen activatorMore data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50138663(2-naphthimidamide | CHEMBL105171 | Naphthalene-2-c...)
Show SMILES NC(=N)c1ccc2ccccc2c1
Show InChI InChI=1S/C11H10N2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,12,13)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards human Tissue type plasminogen activator.More data for this Ligand-Target Pair